Maldi-tof peptidomic profile of faeces for the diagnosis of intestinal inflammatory disease

This patent describes a system for analysing faecal samples capable of diagnosing the main chronic inflammatory bowel diseases (Inflammatory Bowel Diseases - IBD). The peptide extraction method and subsequent MALDI-TOF mass spectrometry analysis allow for a precise and specific diagnosis, particularly of Crohn's disease and ulcerative colitis, as well as colorectal cancer.

INVENTORS
Basso Daniela, Padoan Andrea, Plebani Mario, Arrigoni Giorgio (DSB), D’Incà Renata, Scapellato Maria Luisa.

  Identification of interactions between subcellular organelles with split GFP

The object of this invention is a method to determine the interactions between subcellular organelles in a cell that includes:

• express in this cell or provide this cell with a fusion protein which includes an X localization signal for a first subcellular organelle and an F complementary fragment of a fluorophore, and a fusion protein which includes a Y localization signal for a second subcellular organelle and an F’ complementary fragment of the same fluorophore, where F and F’ are self- complementary to each other and, once self-assembled, they reconstitute the fluorophore;
• display the fluorescent signal and the interaction points between first and second subcellular organelles, where this fluorophore is selected between GFP or its variants.

INVENTORS
Cali Tito (DSB), Brini Marisa (DSB).

  MicroRNA sequences identified in blood cell populations and sub-populations

MicroRNA sequences and other small noncoding RNAs identified by NGS in RNA isolated from sub-populations of T lymphocytes, thymocytes, monocytes/macrophages, granulocytes, eosinophils and from two T-cell lines infected with the retrovirus HTLV-1.

INVENTORS
Guffanti Alessandro, De Bellis Gianluca, Sonda Nada, Bronte Vincenzo, Corradin Alberto, Ghisi Margherita, Ruggero Katia, Zanovello Paola, Ciminale Vincenzo, D'Agostino Donna Mia (DSB).

  Two dimensional and nano materials as mass tags and cell labeling systems in mass cytometry and high dimensional imaging

This invention concerns the use of two-dimensional materials for single-cell mass cytometry and high dimensional imaging. These materials can be used as mass markers for bioimaging, allowing the detection, quantification and chemical characterisation of cells, tissues and organelles. The applications range from cellular tracking and identification to characterisation of biological markers with single-cell resolution.

INVENTORS
Gogotsi Yury, Delogu Lucia Gemma (DSB), Fusco Laura (DSB).

PATENT HOLDERS
YDrexel University, Philadelphia US - Universita' degli studi di Padova.

  New inhibitors of epigenetic regulators

The present invention is directed to a therapeutic agent for use in the treatment of a disease associated with gain-of-function of androgen receptor (AR) and/or with overexpression of an AR coactivator, such as Kennedy disease or cancer. The therapeutic agent of the invention comprises at least one inhibitor of an androgen receptor (AR) coactivator, selected from protein arginine methyltransferase 6 (PRMT6) inhibitor, lysine specific demethylase 1 (LSD1) inhibitor, or combinations thereof.

INVENTORS
Maria Pennuto (DSB), Manuela Basso, Andrea Contestabile, Giuseppe Ronzitti

PATENT HOLDERS
Fondazione Telethon ETS, Universita' degli studi di Padova, Fondazione Istituto Italiano di Tecnologia, Genethon, Università degli Studi di Trento, INSERM, Université d'Evry-Val d'Essonne