Aging signaling pathways

Single cell RNA-seq analysis reveals time-depending increase of heterogeneity

What we do
We are intrigued by why cellular dysfunctions accumulate with time and how such events promote aging and associated diseases such as cancer and neurodegeneration.

We carry out experiments in order to test the hypothesis that the adaptive response to time-intrinsic alterations and environmental contributes to the pathogenic reprogramming of cells. In particular, we investigate the interaction of the aged cellular metabolism and redox balance on genome functions in mouse models and human primary cells using biochemical assays and omics approaches.

process schema

Current projects include the validation of mitochondrial dysfunctions in metastatic disease and the identification of epigenetic signatures shared by aging, cognitive decline and heart failure.

All these activities are in collaboration with:

  • European Institute of Oncology - Milan
  • University of Urbino
  • National Institute on Aging – UCDavis

Follow us on:

Hillje R et al, Aging, 2022 DOI:10.18632/aging.201107



  • Marco GIORGIO - Associate Professor

Lab Members

  • Francesca CASCIARO - Post-doctoral fellow

  Five recent publications

  1. Time makes histone H3 modifications drift in mouse liver. Hillje R, Luzi L, Amatori S, Persico G, Casciaro F, Rusin M, Fanelli M, Pelicci P, Giorgio M. Aging. 2022 Jun 10.
  2. Histone H3 lysine 4 and 27 trimethylation landscape of human alzheimer’s disease. Persico G, Casciaro F, Amatori S, Rusin M, Cantatore F, Perna A, Alberi Auber L, Fanelli M, Giorgio M. Cells. 2022. 11:734.
  3. The early-life stress induced by oxytocin inhibition in p53 knockout mouse dams increases adulthood tumorigenesis in first and second generations. Stendardo M, Renzi C, Pallavi R, Roda N, Gambino V, Casciaro F, Persico G, Giorgio M. Cancer Reports. 2022. e1625.
  4. Aberrant activation of p53/p66Shc-mInsc axis increases asymmetric divisions and attenuates proliferation of aged mammary stem cells. Priami C, Montariello D, De Michele G, Ruscitto F, Polazzi A, Ronzoni S, Bertalot G, Binelli G, Gambino V, Luzi L, Mapelli M, Giorgio M, Migliaccio E, Pelicci PG. Cell Death Differ. 2022 Jun 23.
  5. Hematopoietic and non-hematopoietic p66Shc differentially regulates stem cell traffic and vascular response to ischemia in diabetes. Albiero M, D'Anna M, Bonora BM, Zuccolotto G, Rosato A, Giorgio M, Iori E, Avogaro A, Fadini GP. Antioxid Redox Signal. 2022. 36:593-607.
  6. Hematopoietic progenitor cell liabilities and alarmins S100A8/A9-related inflammaging associate with frailty and predict poor cardiovascular outcomes in older adults. Bonora BM, Palano MT, Testa G, Fadini GP, Sangalli E, Madotto F, Persico G, Casciaro F, Vono R, Colpani O, Scavello F, Cappellari R, Abete P, Orlando P, Carnelli F, Berardi AG, De Servi S, Raucci A, Giorgio M, Madeddu P, Spinetti G. Aging Cell. 2022 Feb 15:e13545.
  7. Hydroxycitric Acid Inhibits Chronic Myelogenous Leukemia Growth through Activation of AMPK and mTOR Pathway. Verrelli D, Dallera L, Stendardo M, Monzani S, Pasqualato S, Giorgio M, Pallavi R. Nutrients. 2022. 14.2669.
  8. Dietary intake of cyanidin-3-glucoside induces a long-lasting cardioprotection from ischemia/reperfusion injury by altering the microbiota. Trinei M, Carpi A, Menabo R, Storto M, Fornari M, Marinelli A, Minardi S, Riboni M, Casciaro F, DiLisa F, Petroni K, Tonelli C, Giorgio M. J Nutr Biochem. 2022. 101: 108921.

  Thesis library

The latest thesis works of our students: Sacco S., 2022, "Exercise and colorectal cancer thesis".

poster Exercise and colorectal cancer thesis