PhD governing board and faculty

Governing Board:

  • Ornella Rossetto (Coordinator)
  • Paola Pizzo (Vice-Coordinator)
  • Giuseppe De Vito
  • Bert Blaauw
  • Maria Ruzzene
  • Carlo Fiore Viscomi

Faculty:

  Ornella Rossetto (Coordinator)

ornella.rossetto@unipd.it

Pubblicazioni:

  1. Fabris F, Megighian A, Rossetto O, Simonato M, Schiavo G, Pirazzini M, Montecucco C. Local Tetanus Begins with a Neuromuscular Junction Paralysis around the Site of Tetanus Neurotoxin Release due to Cleavage of the Vesicle- Associated Membrane Protein. Am J Pathol. 2024 Sep;194(9):1752-1763. doi:10.1016/j.ajpath.2024.05.009.
  2. Rossetto O, Pirazzini M, Montecucco C. Three players in the 'toxic affair' between botulinum neurotoxin type A and neurons. Trends Neurosci. 2023, 46(9):695-697. doi: 10.1016/j.tins.2023.06.001.
  3. Fabris F, Šoštarić P, Matak I, Binz T, Toffan A, Simonato M, Montecucco C, Pirazzini M, Rossetto O. Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody. Int J Mol Sci. 2022 Apr 14;23(8):4355. doi: 10.3390/ijms23084355.
  4. Rossetto O, Montecucco C. Tables of Toxicity of Botulinum and Tetanus Neurotoxins. Toxins (Basel). 2019 Nov 22;11(12):686.
  5. Rossetto O, Pirazzini M, Lista F, Montecucco C. The role of the single interchains disulfide bond in tetanus and botulinum neurotoxins and the development of anti tetanus and anti botulism drugs. Cell Microbiol. 2019 May 3:e13037.

  Paola Pizzo (Vice Coordinator)

paola.pizzo@unipd.it

Pubblicazioni:

  1. García Casas P, Rossini M, et al., Paola Pizzo*, Riccardo Filadi*. (*corresponding author) (2024) Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible chemogenetic reporters. Nature Communications, 15(1):9775
  2. Rossi A., Rigotto G., Valente G., Giorgio V., Basso E., Filadi R. and Pizzo P. (2020). Defective mitochondrial pyruvate flux affects cell bioenergetics in Alzheimer’s disease related models. Cell Reports, 30(7):2332-2348.e10
  3. Fedeli C., Filadi R., Rossi A., Mammucari C. and Pizzo P. (2019) PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca 2+ homeostasis. Autophagy, 20:1-19
  4. Theurey P., Connolly N.M., Fortunati I., Basso E., Lauwen S., Ferrante C., Moreira Pinho C., Joselin A., Gioran A., Bano D., Park D., Ankarcrona M., Pizzo P.* and Prehn J.H.M.* (*corresponding author) (2019)
  5. Systems biology analysis identifies impairment of mitochondrial and glycolytic metabolism in a genetic model of Alzheimer’s disease. Aging Cell, 18(3):e12924. 5. Filadi R., Greotti E., Turacchio G., Luini, A., Pozzan T., Pizzo P. (2016) Presenilin 2 modulates endoplasmic reticulum-mitochondria coupling by tuning the antagonistic effect of mitofusin 2. Cell Reports,15(10):2226-38.

  Manuela Allegra

manuela.allegra@in.cnr.it

  Giorgio Arrigoni

giorgio.arrigoni@unipd.it

Pubblicazioni

  1. PMID: 39779121 DOI: 10.1016/j.foodres.2024.115464 Label-free quantitative proteomics of commercial rice beverages reveals the presence of high amounts of exogenous amylases. Ilaria Battisti, Leonard Barnabas Ebinezer, Giovanna Lomolino, Antonio Masi, Giorgio Arrigoni
  2. PMID: 37878393 DOI: 10.1002/anie.202310230 Site-Specific Ubiquitination of Tau Amyloids Promoted by the E3 Ligase CHIP. Francesca Parolini, Elham Ataie Kachoie, Giulia Leo, Laura Civiero, Luigi Bubacco, Giorgio Arrigoni, Francesca Munari, Michael Assfalg, Mariapina D'Onofrio
  3. PMID: 37013641 DOI: 10.1186/s13045-023-01428-2 PARP1 negatively regulates MAPK signaling by impairing BRAF-X1 translation. Andrea Marranci 1,2,7* , Antonella Prantera, Simona Masotti, Raffaella De Paolo, Caterina Baldanzi, Maurizio S. Podda, Serena Mero, Marianna Vitiello, Cinzia Franchin, Mariavittoria Laezza, Laura Comelli, Giorgio Arrigoni, Tiziana Cervelli, Giovanna Del Pozzo and Laura Poliseno
  4. PMID: 35999737 DOI: 10.1016/j.jhazmat.2022.129512 Perfluorinated alkyl substances affect the growth, physiology and root proteome of hydroponically grown maize plants. Leonard Barnabas Ebinezer, Ilaria Battisti, Nisha Sharma, Laura Ravazzolo, Lokesh Ravi, Anna Rita Trentin, Giuseppe Barion, Anna Panozzo, Stefano Dall’Acqua, Teofilo Vamerali, Silvia Quaggiotti, Giorgio Arrigoni, Antonio Masi
  5. PMID: 37890871 DOI: 10.1021/acs.jafc.3c03065 Subclinical Mastitis from Streptococcus agalactiae and Prototheca spp. Induces Changes in Milk Peptidome in Holstein Cattle Alice Vanzin, Cinzia Franchin, Giorgio Arrigoni, Ilaria Battisti, Antonio Masi, Andrea Squartini, Vittoria Bisutti, Diana Giannuzzi, Luigi Gallo, Alessio Cecchinato, Sara Pegolo

  Alessandro Bertoli

alessandro.bertoli@unipd.it

Pubblicazioni:

  1. PEGGION C, MASSIMINO ML, STELLA R, BORTOLOTTO R, AGOSTINI J, MALDI A, SARTORI G, TONELLO F, BERTOLI A, LOPREIATO R (2021) Nucleolin Rescues TDP-43 Toxicity in Yeast and Human Cell Models. Front. Cell. Neurosci. 15. doi: 10.3389/fncel.2021.625665. IF =5.505
  2. STELLA R, BONADIO RS, CAGNIN S, MASSIMINO ML, BERTOLI A*, PEGGION C (2021) Perturbations of the Proteome and of Secreted Metabolites in Primary Astrocytes from the hSOD1(G93A) ALS Mouse Model. Int. J. Mol. Sci. 22, 7028. doi: 10.3390/ijms22137028. IF =5.923
  3. PEGGION C, MASSIMINO ML, BONADIO RS, LIA F, LOPREIATO R, CAGNIN S, CALI’ T, BERTOLI A* (2021) Regulation of Endoplasmic Reticulum-Mitochondria Tethering and Ca(2+) Fluxes by TDP-43 via GSK3β. Int. J. Mol. Sci. 22, 11853. doi: 10.3390/ijms222111853. IF =5.923
  4. PEGGION C, SCALCON V, MASSIMINO ML, NIES K, LOPREIATO R, RIGOBELLO MP*, BERTOLI A* (2022) SOD1 in ALS: Taking Stock in Pathogenic Mechanisms and the Role of Glial and Muscle Cells. Antioxidants 11, 614. doi: 10.3390/antiox11040614
  5. STELLA R, BONADIO RS, CAGNIN S, ANDREOTTI R, MASSIMINO ML, BERTOLI A, PEGGION C (2023) Secreted Metabolome of ALS-Related hSOD1(G93A) Primary Cultures of Myocytes and Implications for Myogenesis. Cells 12, 2751. doi: 10.3390/cells12232751.
  6. PEGGION C, MASSIMINO ML, PEREIRA D, GRANUZZO S, RIGHETTO F, BORTOLOTTO R, AGOSTINI J, SARTORI G, BERTOLI A, LOPREIATO R (2023) Structural Integrity of Nucleolin Is Required to Suppress TDP-43-Mediated Cytotoxicity in Yeast and Human Cell Models. Int. J. Mol. Sci. 24, 17466. doi: 10.3390/ijms242417466.

  Lucia Biasutto

lucia.biasutto@cnr.it

Pubblicazioni:

  1. Zoratti M et al. Mitochondrial permeability transition pore: a snapshot of a therapeutic target. Expert Opin Ther Targets. 2024;28:1-3. IF 2023 : 4.6
  2. Parrasia S et al. DA7R: A 7-Letter Zip Code to Target PDAC. Pharmaceutics. 2023;15:1508. IF 2023 : 5.4
  3. Parrasia S et al. An Angiopep2-PAPTP Construct Overcomes the Blood-Brain Barrier. New Perspectives against Brain Tumors.Pharmaceuticals (Basel). 2021;14:129. IF 2021 : 5.215
  4. Peruzzo R et al. Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction. Nat Commun. 2021;12:2103 IF 2021 : 17.694
  5. Szabo I et al. Targeting mitochondrial ion channels for cancer therapy. Redox Biol 2020:101846. IF 2021 : 10.787.

  Bert Blaauw

bert.blaauw@unipd.it

Pubblicazioni:

  1. De Napoli C, Schmidt L, Montesel M, Cussonneau L, Sanniti S, Marcucci L, Germinario E, Kindberg J, Evans AL, Gauquelin-Koch G, Narici M, Bertile F, Lefai E, Krüger M, Nogara L, Blaauw B. Reduced ATP turnover during hibernation in relaxed skeletal muscle. Nat Commun. 2025 Jan 2;16(1):80.
  2. Germani S, Van Ho AT, Cherubini A, Varone E, Chernorudskiy A, Renna GM, Fumagalli S, Gobbi M, Lucchetti J, Bolis M, Guarrera L, Craparotta I, Rastelli G, Piccoli G, de Napoli C, Nogara L, Poggio E, Brini M, Cattaneo A, Bachi A, Simmen T, Calì T, Quijano-Roy S, Boncompagni S, Blaauw B, Ferreiro A, Zito E. SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA. Cell Rep Med. 2024 Feb 19:101439.
  3. Geremia A, Sartori R, Baraldo M, Nogara L, Balmaceda V, Dumitras GA, Ciciliot S, Scalabrin M, Nolte H, Blaauw B.Activation of Akt-mTORC1 signaling reverts cancer-dependent muscle wasting. Journal of Cachexia, Sarcopenia and Muscle, 2022 Feb;13(1):648-661
  4. Baraldo M, Geremia A, Pirazzini M, Nogara L, Solagna F, Türk C, Nolte H, Romanello V, Megighian A, Boncompagni S, Kruger M, Sandri M, Blaauw B. Skeletal muscle mTORC1 regulates neuromuscular junction stability. Journal of Cachexia, Sarcopenia and Muscle, 2020 Feb;11(1):208-225.
  5. Solagna F, Nogara L, Dyar KA, Greulich F, Mir AA, Türk C, Geremia A, Baraldo M, Sartori R, Farup J, Uhlenhaut H, VissingK, Kruger M, Blaauw B. Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling. Acta Physiologica, 2020 Sep; 230 (1)

  Christian Borgo

christian.borgo@unipd.it 

Pubblicazioni:

  1. Quezada Meza CP, Salizzato V, Calistri E, Basso M, Zavatti M, Marmiroli S, Salvi M, Carter BZ, Donella-Deana A, Borgo C*, Ruzzene M. Critical role of protein kinase CK2 in chronic myeloid leukemia cells harboring the T315I BCR::ABL1 mutation. Int J Biol Macromol. 2025 Jan;286:138305. doi: 10.1016/j.ijbiomac.2024.138305. *co-corresponding author
  2. Borgo C, D'Amore C, Capurro V, Tomati V, Pedemonte N, Bosello Travain V, Salvi M. SUMOylation Inhibition Enhances Protein Transcription under CMV Promoter: A Lesson from a Study with the F508del-CFTR Mutant. Int J Mol Sci. 2024 Feb 15;25(4). doi: 10.3390/ijms25042302.
  3. Borgo C, Cesaro L, Hirota T, Kuwata K, D'Amore C, Ruppert T, Blatnik R, Salvi M, Pinna LA. Analysis of the phosphoproteome of CK2α((-/-))/Δα' C2C12 myoblasts compared to the wild-type cells. Open Biol. 2023 Feb;13(2):220220. doi: 10.1098/rsob.220220.
  4. Borgo C, D'Amore C, Sarno S, Salvi M, Ruzzene M. Protein kinase CK2: a potential therapeutic target for diverse human diseases. Signal Transduct Target Ther. 2021 May 17;6(1):183. doi: 10.1038/s41392-021-00567-7.
  5. Borgo C*, D'Amore C, Capurro V, Tomati V, Sondo E, Cresta F, Castellani C, Pedemonte N, Salvi M. Targeting the E1 ubiquitin-activating enzyme (UBA1) improves elexacaftor/tezacaftor/ivacaftor efficacy towards F508del and rare misfolded CFTR mutants. Cell Mol Life Sci. 2022 Mar 16;79(4):192. doi: 10.1007/s00018-022-04215-3. *co- corresponding author

  Tito Calì

tito.cali@unipd.it

Pubblicazioni:

  1. Cieri, D., Vicario, M., Giacomello, M., Vallese, F., Filadi, R., Wagner, T., Pozzan, T., Pizzo, P., Scorrano, L., Brini, M. & Cali, T. SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition. Cell Death Differ 25, 1131-1145, doi:10.1038/s41418-017-0033- z (2018).
  2. Vallese F, Catoni C, Cieri D, Barazzuol L, Ramirez O, Calore V, Bonora M, Giamogante F, Pinton P, Brini M, Calì T. An expanded palette of improved SPLICS reporters detects multiple organelle contacts in vitro and in vivo. Nat Commun. 2020 Nov 27;11(1):6069. doi: 10.1038/s41467-020-19892-6.
  3. Giamogante F, Barazzuol L, Maiorca F, Poggio E, Esposito A, Masato A, Napolitano G, Vagnoni A, Calì T, Brini M. A SPLICS reporter reveals [Formula: see text]-synuclein regulation of lysosome-mitochondria contacts which affects TFEB nuclear translocation. Nat Commun. 2024 Feb 19;15(1):1516. doi: 10.1038/s41467-024-46007-2.
  4. Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Calì T, Clarke OB. Architecture of the human erythrocyte ankyrin-1 complex. Nat Struct Mol Biol. 2022 Jul;29(7):706-718. doi: 10.1038/s41594-022-00792-w
  5. Calì T, Brini M. Quantification of organelle contact sites by split-GFP-based contact site sensors (SPLICS) in living cells. Nat Protoc. 2021 Nov;16(11):5287-5308. doi: 10.1038/s41596-021-00614-1

  Michelangelo Campanella

michelangelo.campanella@unipd.it

Pubblicazioni:

  1. Campanella M, Kannan B; Mitochondrial sites of contact with the nucleus. J Cell Biol 3 June 2024; 223 (6): e202305010. doi: https://doi.org/10.1083/jcb.202305010
  2. Rigon M, Townley AR and Campanella M. Mitochondria ensure immune surveillance by retro- communication with the nucleus. Cell Met. (2021) doi.org/10.1016/j.cmet.2021.04.013
  3. Frison M, Strobbe D, Faccenda D, Rigon M, Abeti R, Cash D, England-Rendon BS, Barnes K, Sadeghian M, Sajic M, Wells LA, Giunti P, Xia D, Smith K, Mortiboys H, Turkheimer F and Campanella M. The Translocator Protein (TSPO) is prodromal to mitophagy loss in Neurotoxicity. Mol. Psychiatry (2021). doi.org/10.1038/s41380-021-01050-z
  4. Singh A, Faccenda D, Campanella M. Pharmacological advances in mitochondrial therapy. EBioMedicine. 2021 Mar;65:103244. doi: 10.1016/j.ebiom.2021.103244
  5. Desai R, East DA, Hardy L, Crosby J, Rigon M, Faccenda D, Alvarez MS, Singh A, Mainenti M, Kuhlman-Hussey L, Bentham R, Szabadkai G, Zappulli V, Dhoot G, Romano L, Xia D, Hamechar-Brady A, Chapple P, Fleck R, Vizcay-Barrena G, Smith K and Campanella M. Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response. Sci Adv 2020 Dec 18;6(51):eabc9955. doi: 10.1126/sciadv.abc9955

  Marcella Canton

marcella.canton@unipd.it

Pubblicazioni:

  1. Sánchez-Rodríguez R, Munari F, Angioni R, Venegas F, Agnellini A, Castro-Gil MP, Castegna A, Luisetto R, Viola A, Canton M (2020) Targeting monoamine oxidase to dampen NLRP3 inflammasome activation in inflammation. Cell Mol Immunol. 18(5):1311-1313
  2. Castegna A, Gissi R, Menga A, Montopoli M, Viola A, Canton M (2020) Pharmacological targets of metabolism in disease: opportunities from macrophages Pharmacol. Ther. 210:107521
  3. Canton M, Sánchez-Rodríguez R, Spera I, Venegas FC, Favia M, Viola A, Castegna A (2021) Reactive Oxygen Species in Macrophages: Sources and Targets Front Immunol https://doi.org/10.3389/fimmu.2021.734229
  4. Menga A, Favia M, Spera I, Vegliante MC, Gissi R, De Grassi A, Laera L, Campanella A, Andrea Gerbino A, Carrà G, Canton M, Loizzi V, Pierri C, Cormio G, Mazzone M, Castegna A (2021) N- acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages. EMBO Rep ISSN:1469-221X pp. e5198
  5. Spera, I., Sánchez-Rodríguez, R., Favia, M., ... Canton, M., Castegna, A. (2021). The J2-immortalized murine macrophage cell line displays phenotypical and metabolic features of primary BMDMs in their M1 and M2 polarization state. Cancers, 13(21), 5478
  6. Carraro, E, Rossi, L, Maghin, E, Canton, M, Piccoli, M. (2022) 3D in vitro Models of Pathological Skeletal Muscle: Which Cells and Scaffolds to Elect? Front Bioeng Biotechnol, 10, 941623
  7. Venegas F.C., Sanchez-Rodríguez R, Luisetto R, Angioni R, Viola A, Canton M (2023) Oxidative Stress by the Mitochondrial Monoamine Oxidase B Mediates Calcium Pyrophosphate Crystal- Induced Arthritis. Arthritis Rheumatol. https://dx.doi.org/10.1002/art.42697
  8. Sánchez-Rodríguez R, Tezze C, Agnellini A, Angioni R, Venegas F, Cioccarelli C, Munari F, Bertoldi N, Canton M, Desbats, M.A., Salviati L, Gissi R, Castegna A, Soriano ME, Sandri M, Scorrano L, Viola A*, Molon, B* (2023). OPA1 drives macrophage metabolism and functional commitment via p65 signaling. Cell Death Diff, 30(3), pp. 742–752
  9. Gasparella, F., Nogara, L., Germinario, E., ... Canton, M., Vitiello L (2024). A Novel MAO-B/SSAO Inhibitor Improves Multiple Aspects of Dystrophic Phenotype in mdx mice. Antioxidants, 13(6), 622.

  Francesco Ciscato

francesco.ciscato@cnr.it

Pubblicazioni:

  1. DOI: 10.15252/embr.201949117
  2. DOI: 10.3390/ijms22094716
  3. DOI: 10.3390/cells13131162
  4. DOI: 10.1038/s41418-022-00991-4
  5. DOI: 10.1038/s42003-024-07172-8

  Diego De Stefani

diego.destefani@unipd.it

Pubblicazioni:

  1. De Stefani D, Raffaello A, Teardo E, Szabò I, Rizzuto R. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature. 2011 Jun 19;476(7360):336-40. doi: 10.1038/nature10230. PubMed PMID: 21685888. (IF: 69.504, > 1700 citations)
  2. Raffaello A, De Stefani D*, Sabbadin D, Teardo E, Merli G, Picard A, Checchetto V, Moro S, Szabò I, Rizzuto R. The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. EMBO J. 2013 Aug 28;32(17):2362-76. doi: 10.1038/emboj.2013.157. Epub 2013 Jul 30. PubMed PMID: 23900286; PubMed Central PMCID: PMC3771344. *co-first author (IF: 14.012, > 430 citations)
  3. Patron M, Checchetto V, Raffaello A, Teardo E, Vecellio Reane D, Mantoan M, Granatiero V, Szabò I, De Stefani D*, Rizzuto R. MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity. Mol Cell. 2014 Mar 6;53(5):726-37. doi: 10.1016/j.molcel.2014.01.013. Epub 2014 Feb 20. PubMed PMID: 24560927; PubMed Central PMCID: PMC3988891. *co-corresponding author (IF: 19.328, > 460 citations)
  4. Patron M, Granatiero V, Espino J, Rizzuto R, De Stefani D*. MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake. Cell Death Differ. 2019 Jan;26(1):179-195. doi: 10.1038/s41418-018-0113-8. Epub 2018 May 3. PubMed PMID: 29725115; PubMed Central PMCID: PMC6124646. *co-corresponding author (IF: 12.077, > 120 citations)
  5. Paggio A, Checchetto V, Campo A, Menabò R, Di Marco G, Di Lisa F, Szabo I, Rizzuto R, De Stefani D. Identification of an ATP-sensitive potassium channel in mitochondria. Nature. 2019 Aug;572(7771):609-613. doi: 10.1038/s41586-019-1498-3. Epub 2019 Aug 21. PubMed PMID: 31435016; PubMed Central PMCID: PMC6726485. (IF: 69.504, > 150 citations)

  Giuseppe De Vito

giuseppe.devito@unipd.it

Pubblicazioni:

  1. Plasma C-terminal agrin fragment concentrations across adulthood: Reference values and associations with skeletal muscle health. Pratt J, Motanova E, Pessanha L, Narici M, Boreham C, De Vito G. J Cachexia Sarcopenia Muscle. 2024 Aug;15(4):1501-1510. doi: 10.1002/jcsm.13507. Epub 2024 Jun 7.
  2. Altered muscle mitochondrial, inflammatory and trophic markers, and reduced exercise training adaptations in type 1 diabetes. Minnock D, Annibalini G, Valli G, Saltarelli R, Krause M, Barbieri E, De Vito G. J Physiol. 2022 Mar;600(6):1405-1418. doi: 10.1113/JP282433. Epub 2022 Jan 24.
  3. Neuromodulatory Contribution to Muscle Force Production after Short-Term Unloading and Active Recovery. Martino G, Valli G, Sarto F, Franchi MV, Narici MV, DE Vito G. Med Sci Sports Exerc. 2024 Sep 1;56(9):1830-1839. doi: 10.1249/MSS.0000000000003473. Epub 2024.
  4. Lower limb suspension induces threshold-specific alterations of motor units properties that are reversed by active recovery. Valli G, Sarto F, Casolo A, Del Vecchio A, Franchi MV, Narici MV, De Vito G. J Sport Health Sci. 2024 Mar;13(2):264-276. doi: 10.1016/j.jshs.2023.06.004. Epub 2023 Jun 17.
  5. Plasma neurofilament light levels associate with muscle mass and strength in middle- aged and older adults: findings from GenoFit. Pratt J, De Vito G, Segurado R, Pessanha L, Dolan J, Narici M, Boreham C. J Cachexia Sarcopenia Muscle. 2022 Jun;13(3):1811-1820. doi: 10.1002/jcsm.12979. Epub 2022 Apr 13.

  Lucia Gemma De Logu

luciagemma.delogu@unipd.it 

Pubblicazioni:

  1. Nanoplastics: Immune Impact, Detection, and Internalization after Human Blood Exposure by Single-Cell Mass Cytometry. Fusco L, et al. Among authors: delogu lg. Adv Mater. 2024. PMID: 39449193
  2. Immune Profiling and Multiplexed Label-Free Detection of 2D MXenes by Mass Cytometry and High-Dimensional Imaging. Fusco L, et al. Among authors: delogu lg. Adv Mater. 2022. PMID: 36207284
  3. Immune profiling and tracking of two-dimensional transition metal dichalcogenides in cells and tissues Arianna Gazzi a 1, Laura Fusco a b 1, Marco Orecchioni c, Sandeep Keshavan d, Yuyoung Shin e, Jean-Charles Grivel f, Darawan Rinchai b, Eiman I. Ahmed b, Ofer Elhanani g, Giulia Furesi h, Martina Rauner i, Leeat Keren g, Klaus Ley c j, Cinzia Casiraghi e, Davide Bedognetti b k l , Bengt Fadeel d, Lucia Gemma Delogu

  Gabriele Deidda

g.deidda@qmul.ac.uk

  Giulietta Di Benedetto

giulietta.dibenedetto@cnr.it

Pubblicazioni:

  1. Noè R, Inglese N, Romani P, Serafini T, Paoli C, Calciolari B, Fantuz M, Zamborlin A, Surdo NC, Spada V, Spacci M, Volta S, Ermini ML, Di Benedetto G, Frusca V, Santi C, Lefkimmiatis K, Dupont S, Voliani V, Sancineto L, Carrer A. Organic Selenium induces ferroptosis in pancreatic cancer cells. Redox Biol. 68: 102962 (2023). doi: 10.1016/j.redox.2023.102962. PMID: 38029455
  2. Iannucci LF, D'Erchia AM, Picardi E, Bettio D, Conca F, Surdo NC, Di Benedetto G, Musso D, Arrigoni C, Lolicato M, Vismara M, Grisan F, Salviati L, Milanesi L, Pesole G, Lefkimmiatis K. Cyclic AMP induces reversible EPAC1 condensates that regulate histone transcription. Nat Commun. 14(1):5521 (2023). doi: 10.1038/s41467-023-41088-x.PMID: 37684224
  3. Di Benedetto G#, Lefkimmiatis K, Pozzan T. The basics of mitochondrial cAMP signalling: when, where, why. Cell calcium 93, 102320 (2021)PMID: 33296837
  4. Lefkimmiatis K, Grisan F, Iannucci LF, Surdo NC, Pozzan T, Di Benedetto G#. Mitochondrial communication in the context of aging. Aging Clin Exp Res 33(5) 1367-1370 (2021) doi: 10.1007/s40520-019-01451-9. PMID: 31925726
  5. Grisan F., Iannucci L., Zanin S., Surdo N.C., Gerbino A., Di Benedetto G, Pozzan T., Lefkimmiatis K. PKA compartmentalization links cAMP signalling and autophagy. Cell Death Diff, 28(8) 2436–2449 (2021) doi: 10.1038/s41418-021-00761-8.PMID: 33742135

  Riccardo Filadi

riccardo.filadi@unipd.it

Pubblicazioni:

  1. García Casas P, Rossini M, Påvénius L, Saeed M, Arnst N, Sonda S, Fernandes T, D'Arsiè I, Bruzzone M, Berno V, Raimondi A, Sassano ML, Naia L, Barbieri E, Sigismund S, Agostinis P, Sturlese M, Niemeyer BA, Brismar H, Ankarcrona M, Gautier A, Pizzo P, Filadi R. Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible chemogenetic reporters. Nat Commun. 15(1):9775 (2024)
  2. Rossi A, Rigotto G, Valente G, Giorgio V, Basso E, Filadi R*, Pizzo P*. Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models. Cell Reports 30: 2332- 2348.e10 (2020). *co-corresponding author
  3. Fedeli C.*, Filadi R.*, Rossi A., Mammucari C., Pizzo P. PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis. Autophagy 15: 2044-2062 (2019). *co- first author
  4. Filadi R, Leal NS, Schreiner B, Rossi A, Dentoni G, Pinho CM, Wiehager B, Cieri D, Calì T, Pizzo P, Ankarcrona M. TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer. Current Biology 28(3):369-382 (2018)
  5. Filadi R, Greotti E, Turacchio G, Luini A, Pozzan T, Pizzo P. Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling. Proceedings of the National Academy of Sciences (PNAS) 112(17):E2174- 81 (2015).

  Martino Franchi

martino.franchi@unipd.it

Pubblicazioni:

  1. Franchi M V., Candia J, Sarto F, Sirago G, Valli G, Paganini M, Hartnell L, Giacomello E, Toniolo L, Monti E, Nogara L, Moro T, Paoli A, Murgia M, Brocca L, Pellegrino MA, Grassi B, Bottinelli R, De Vito G, Ferrucci L, Narici M V. Previous short-term disuse dictates muscle gene expression and physiological adaptations to subsequent resistance exercise. The Journal of Physiology, 2025
  2. Franchi M V, Sarto F, Simunič B, Pišot R, Narici M V. Early Changes of Hamstrings Morphology and Contractile Properties During 10 Days of Complete Inactivity. Med. Sci. Sports Exerc. ( March 23, 2022). doi: 10.1249/MSS.0000000000002922
  3. Ritsche P, Wirth P, Cronin N, Sarto F, Narici M V., Faude O, Franchi M V. DeepACSA: Automatic Segmentation of Cross-sectional Area in Ultrasound Images of Lower Limb Muscles Using Deep Learning. Med Sci Sport Exerc , 2022
  4. Sarto F, Spörri J, Fitze DP, Quinlan JI, Narici M V, Franchi M V. Implementing Ultrasound Imaging for the Assessment of Muscle and Tendon Properties in Elite Sports : Practical Aspects , Methodological Considerations and Future Directions. Sport. Med. ( March 8, 2021). doi: 10.1007/s40279-021-01436-7
  5. Monte A, Franchi M V. Regional muscle features and their association with knee extensors force production at a single joint angle. European journal of applied physiology 123: 2239–2248, 2023. doi: 10.1007/S00421-023-05237-W.

  Monika Fuxreiter

monika.fuxreiter@unipd.it

Pubblicazioni:

  1. M Fuxreiter* (2024) How proteins sense their cellular environment Nature Reviews Mol. Cell Biol DOI:  https://doi.org/10.1038/s41580-024-00812-1
  2. M. Fuxreiter* and M. Vendruscolo (2021) Generic nature of the condensed state of proteins. Nat Cell Biol 23, 587-594. doi: 10.1038/s41556-021-00697-8
  3. M. Vendruscolo, M Fuxreiter* (2022) Protein Condensation Diseases: Therapeutic Opportunities. Nat Commun 13, 5500, doi:  10.1038/s41467-022-32940-7
  4. Hardenberg M, Horvath A, Ambrus V, Fuxreiter M*, Vendruscolo M.* (2020) Widespread occurrence of the droplet state of proteins in the human proteome. Proc Natl Acad Sci U S A. 117, 33254-33262. DOI:  10.1073/pnas.2007670117
  5. Gönczi M., Teixeira JMC, Barrera-Vilarmau S., Mediani L. , Antoniani F. , Nagy TM, Fehér K., Ráduly Z., Ambrus V . , Tőzsér J., Barta E., Kövér KE., Csernoch L., Carra S. , Fuxreiter M.* (2023) Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis Nature Communications 14, 1329 (1-13). DOI:  10.1038/s41467-023-37017-7
  6. Fuxreiter M. (2022) Electrostatics tunes protein interactions to context. Proc Natl Acad Sci U S A. 119, e2209201119. doi: 10.1073/pnas.2209201119. 
  7. Gianni S, Freiberger MI, Jemth P, Ferreiro DU, Wolynes PG, Fuxreiter M.* (2021) Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly. Acc Chem Res 54, 1251-1259 DOI:  10.1021/acs.accounts.0c00813

  Marco Giorgio

marco.giorgio@unipd.it

Pubblicazioni:

  1. Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer's mouse model and stimulates synaptic plasticity pathway enzymes. Di Lucente J, Persico G, Zhou Z, Jin LW, Ramsey JJ, Rutkowsky JM, Montgomery CM, Tomilov A, Kim K, Giorgio M, Maezawa I, Cortopassi GA. Commun Biol. 2024. 7:195.
  2. The early-life stress induced by oxytocin inhibition in p53 knockout mouse dams increases adulthood tumorigenesis in first and second generations. Stendardo M, Renzi C, Pallavi R, Roda N, Gambino V, Casciaro F, Persico G, Giorgio M. Cancer Reports. 2023. 6:e1625.
  3. Dietary intake of cyanidin-3-glucoside induces a long-lasting cardioprotection from ischemia/reperfusion injury by altering the microbiota. Trinei M, Carpi A, Menabo R, Storto M, Fornari M, Marinelli A, Minardi S, Riboni M, Casciaro F, DiLisa F, Petroni K, Tonelli C, Giorgio M. J Nutr Biochem. 2022. 101: 108921.
  4. Histone H3 lysine 4 and 27 trimethylation landscape of human alzheimer’s disease. Persico G, Casciaro F, Amatori S, Rusin M, Cantatore F, Perna A, Alberi Auber L, Fanelli M, Giorgio M. Cells. 2022, 11;734.
  5. Time makes histone H3 modifications drift in mouse liver. Hillje R, Luzi L, Amatori S, Persico G, Casciaro F, Rusin M, Fanelli M, Pelicci P, Giorgio M. Aging. 2022 14:4959-4975.

  Marta Gomez-Gonzalo

marta.gomezgonzalo@cnr.it

Pubblicazioni:

  1. Michele Speggiorin, Angela Chiavegato, Micaela Zonta, Marta Gómez-Gonzalo&. “Characterization of the Astrocyte Calcium Response to Norepinephrine in the Ventral Tegmental Area”, Cells, 2024, 14(1):1-24. https://doi.org/10.3390/cells14010024
  2. Giorgio Carmignoto&, Marta Gómez-Gonzalo. “A new role for astrocytes in the story of cocaine abuse”, Neuron, 2023, 111(7):920-921. https://doi.org/10.1016/j.neuron.2023.03.004
  3. Vanessa Jorge Henriques, Angela Chiavegato, Giorgio Carmignoto1, Marta Gómez-Gonzalo1,&. “Astrocytes modulate somatostatin interneuron signaling in the visual cortex”, Cells, 2022, 11(9):1400. https://doi.org/10.3390/cells11091400
  4. Linda Maria Requie1, Marta Gómez-Gonzalo1,&, Michele Speggiorin1, Francesca Managò, Marcello Melone, Mauro Congiu, Angela Chiavegato, Annamaria Lia, Micaela Zonta, Gabriele Losi, Vanessa Jorge Henriques, Arianna Pugliese, Giada Pacinelli, Giovanni Marsicano, Francesco Papaleo, Anna Lisa Muntoni, Fiorenzo Conti, Giorgio Carmignoto& “Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons”, Nature Neuroscience, 2022, 25(12):1639-1650. https://doi.org/10.1038/s41593-022-01193-4
  5. Annamaria Lia, Vanessa Jorge Henriques, Micaela Zonta, Angela Chiavegato, Giorgio Carmignoto, Marta Gómez-Gonzalo&, Gabriele Losi& “Calcium signals in astrocyte microdomains, a decade of great advances”, Frontiers in Cellular Neuroscience, 2021, 15:673433. https://doi.org/10.3389/fncel.2021.673433 1 These authors contributed equally & Corresponding author

  Elisa Greotti

elisa.greotti@unipd.it

Pubblicazioni:

  1. Delgado de la Herran H, Vecellio Reane D, Cheng Y, Katona M, Hosp F, Greotti E, Wettmarshausen J, Patron M, Mohr H, Prudente de Mello N, Chudenkova M, Gorza M, Walia S, Feng MS, Leimpek A, Mielenz D, Pellegata NS, Langer T, Hajnóczky G, Mann M, Murgia M, Perocchi F. Systematic mapping of mitochondrial calcium uniporter channel (MCUC)-mediated calcium signaling networks. EMBO J. 2024 Nov;43(21):5288-5326
  2. Rossi A, Galla L, Gomiero C, Zentilin L, Giacca M, Giorgio V, Calì T, Pozzan T, Greotti E, Pizzo P. Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of- Function Phenotype Related to Alzheimer's Disease. Cells. 2021 Jan 21;10(2):204
  3. Greotti E, Fortunati I, Pendin D, Ferrante C, Galla L, Zentilin L, Giacca M, Kaludercic N, Di Sante M, Mariotti L, Lia A, Gómez-Gonzalo M, Sessolo M, Di Lisa F, Carmignoto G, Bozio R, Pozzan T. mCerulean3-Based Cameleon Sensor to Explore Mitochondrial Ca2+ Dynamics In Vivo. iScience. 2019 Jun 28;16:340-355.
  4. Greotti E, Capitanio P, Wong A, Pozzan T, Pizzo P, Pendin D. Familial Alzheimer's disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis. Cell Calcium. 2019 May;79:44-56.
  5. Tkatch T, Greotti E, Baranauskas G, Pendin D, Roy S, Nita LI, Wettmarshausen J, Prigge M, Yizhar O, Shirihai OS, Fishman D, Hershfinkel M, Fleidervish IA, Perocchi F, Pozzan T, Sekler I. Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5167-E5176.

  Nina Kaludercic

nina.kaludercic@unipd.it

Pubblicazioni:

  1. Di Sante M, Antonucci S, Pontarollo L, Cappellaro I, Segat F, Deshwal S, Greotti E, Grilo L, Menabò R, Di Lisa F, Kaludercic N. Monoamine oxidase A- dependent ROS formation modulates human cardiomyocyte differentiation through AKT and WNT activation. Basic Res Cardiol. 2023 Jan 20;118(1):4. 
  2. Cagnin S, Brugnaro M, Millino C, Pacchioni B, Troiano C, Di Sante M, Kaludercic N. Monoamine Oxidase-Dependent Pro-Survival Signaling in Diabetic Hearts Is Mediated by miRNAs. Cells. 2022 Aug 30;11(17):2697.
  3. Wang Y, Zhao M, Xu B, Bahriz SMF, Zhu C, Jovanovic A, Ni H, Jacobi A, Kaludercic N, Di Lisa F, Hell JW, Shih JC, Paolocci N, Xiang YK. Monoamine oxidase A and organic cation transporter 3 coordinate intracellular β 1 AR signaling to calibrate cardiac contractile function. Basic Res Cardiol. 2022 Jul 17;117(1):37.
  4. Kaludercic N*, Arusei RJ, Di Lisa F*. Recent advances on the role of monoamine oxidases in cardiac pathophysiology. Basic Res Cardiol. 2023 Oct 4;118(1):41. doi: 10.1007/s00395-023- 01012-2. *co-corresponding authors
  5. Alanova P, Alan L, Opletalova B, Bohuslavova R, Abaffy P, Matejkova K, Holzerova K, Benak D, Kaludercic N, Menabo R, Di Lisa F, Ostadal B, Kolar F, Pavlinkova G. HIF-1α limits myocardial infarction by promoting mitophagy in mouse hearts adapted to chronic hypoxia. Acta Physiol (Oxf). 2024 Sep;240(9):e14202.

  Thomas Krieg

tk382@medschl.cam.ac.uk

  Emanuela Leonardi

emanuela.leonardi@unipd.it

Pubblicazioni:

  1. Critical Assessment of Genome Interpretation Consortium. CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods. Genome Biol. 2024 Feb 22;25(1):53. doi: 10.1186/s13059-023-03113-6. PMID: 38389099; PMCID: PMC10882881
  2. Gehin C, Lone MA, Lee W, Capolupo L, Ho S, Adeyemi AM, Gerkes EH, Stegmann AP, López-Martín E, Bermejo-Sánchez E, Martínez-Delgado B, Zweier C, Kraus C, Popp B, Strehlow V, Gräfe D, Knerr I, Jones ER, Zamuner S, Abriata LA, Kunnathully V, Moeller BE, Vocat A, Rommelaere S, Bocquete JP, Ruchti E, Limoni G, Van Campenhoudt M, Bourgeat S, Henklein P, Gilissen C, van Bon BW, Pfundt R, Willemsen MH, Schieving JH, Leonardi E, Soli F, Murgia A, Guo H, Zhang Q, Xia K, Fagerberg CR, Beier CP, Larsen MJ, Valenzuela I, Fernández-Álvarez P, Xiong S, Śmigiel R, López-González V, Armengol L, Morleo M, Selicorni A, Torella A, Blyth M, Cooper NS, Wilson V, Oegema R, Herenger Y, Garde A, Bruel AL, Tran Mau-Them F, Maddocks AB, Bain JM, Bhat MA, Costain G, Kannu P, Marwaha A, Champaigne NL, Friez MJ, Richardson EB, Gowda VK, Srinivasan VM, Gupta Y, Lim TY, Sanna-Cherchi S, Lemaitre B, Yamaji T, Hanada K, Burke JE, Jakšić AM, McCabe BD, De Los Rios P, Hornemann T, D'Angelo G, Gennarino VA. CERT1 mutations perturb human development by disrupting sphingolipid homeostasis. J Clin Invest. 2023 May 15;133(10):e165019. doi: 10.1172/JCI165019. PMID: 36976648; PMCID: PMC10178846
  3. Cousin MA, Veale EL, Dsouza NR, Tripathi S, Holden RG, Arelin M, Beek G, Bekheirnia MR, Beygo J, Bhambhani V, Bialer M, Bigoni S, Boelman C, Carmichael J, Courtin T, Cogne B, Dabaj I, Doummar D, Fazilleau L, Ferlini A, Gavrilova RH, Graham JM Jr, Haack TB, Juusola J, Kant SG, Kayani S, Keren B, Ketteler P, Klöckner C, Koopmann TT, Kruisselbrink TM, Kuechler A, Lambert L, Latypova X, Lebel RR, Leduc MS, Leonardi E, Lewis AM, Liew W, Machol K, Mardini S, McWalter K, Mignot C, McLaughlin J, Murgia A, Narayanan V, Nava C, Neuser S, Nizon M, Ognibene D, Park J, Platzer K, Poirsier C, Radtke M, Ramsey K, Runke CK, Guillen Sacoto MJ, Scaglia F, Shinawi M, Spranger S, Tan ES, Taylor J, Trentesaux AS, Vairo F, Willaert R, Zadeh N, Urrutia R, Babovic-Vuksanovic D, Zimmermann MT, Mathie A, Klee EW. Gain and loss of TASK3 channel function and its regulation by novel variation cause KCNK9 imprinting syndrome. Genome Med. 2022 Jun 13;14(1):62. doi: 10.1186/s13073-022-01064-4. PMID: 35698242; PMCID: PMC9195326
  4. Godler DE, Ling L, Gamage D, Baker EK, Bui M, Field MJ, Rogers C, Butler MG, Murgia A, Leonardi E, Polli R, Schwartz CE, Skinner CD, Alliende AM, Santa Maria L, Pitt J, Greaves R, Francis D, Oertel R, Wang M, Simons C, Amor DJ. Feasibility of Screening for Chromosome 15 Imprinting Disorders in 16 579 Newborns by Using a Novel Genomic Workflow. JAMA Netw Open. 2022 Jan 4;5(1):e2141911. doi: 10.1001/jamanetworkopen.2021.41911. PMID: 34982160; PMCID: PMC8728620
  5. Quaglia F, Mészáros B, Salladini E, Hatos A, Pancsa R, Chemes LB, Pajkos M, Lazar T, Peña-Díaz S, Santos J, Ács V, Farahi N, Fichó E, Aspromonte MC, Bassot C, Chasapi A, Davey NE, Davidović R, Dobson L, Elofsson A, Erdős G, Gaudet P, Giglio M, Glavina J, Iserte J, Iglesias V, Kálmán Z, Lambrughi M, Leonardi E, Longhi S, Macedo-Ribeiro S, Maiani E, Marchetti J, Marino-Buslje C, Mészáros A, Monzon AM, Minervini G, Nadendla S, Nilsson JF, Novotný M, Ouzounis CA, Palopoli N, Papaleo E, Pereira PJB, Pozzati G, Promponas VJ, Pujols J, Rocha ACS, Salas M, Sawicki LR, Schad E, Shenoy A, Szaniszló T, Tsirigos KD, Veljkovic N, Parisi G, Ventura S, Dosztányi Z, Tompa P, Tosatto SCE, Piovesan D. DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation. Nucleic Acids Res. 2022 Jan 7;50(D1):D480-D487. doi: 10.1093/nar/gkab1082. PMID: 34850135; PMCID: PMC8728214

  Fabio Mammano

fabio.mammano@unipd.it

Pubblicazioni:

  1. Tettey-Matey A, et al (2024), Cell Commun Signal, DOI: 10.1186/s12964-024-01988-x
  2. Peres C, et al. (2023), EBIOMEDICINE, DOI: 10.1016/j.ebiom.2023.104453
  3. Donati V, et al. (2022). FUNCTION, 3, zqab064. DOI: 10.1093/function/zqab064
  4. Kuang Y, et al. EBIOMEDICINE 57:102825. DOI:10.1016/j.ebiom.2020.102825.102825
  5. Cacheiro P, et al. (2020) NATURE COMMUNICATIONS 11, 655. DOI: 10.1038/s41467-020-14284-2

  Cristina Mammucari

cristina.mammucari@unipd.it

Pubblicazioni:

  1. Gherardi G, Weiser A, Bermont F, Migliavacca E, Brinon B, Jacot GE, Hermant A, Sturlese M, Nogara L, Vascon F, De Mario A, Mattarei A, Garratt E, Burton M, Lillycrop K, Godfrey KM, Cendron L, Barron D, Moro S, Blaauw B, Rizzuto R, Feige JN, Mammucari C, De Marchi U. Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance. Cell Metab. 2024 Nov 23:S1550-4131(24)00417-0. doi: 10.1016/j.cmet.2024.10.021. Epub ahead of print. PMID: 39603237
  2. Di Marco G, Gherardi G, De Mario A, Piazza I, Baraldo M, Mattarei A, Blaauw B, Rizzuto R, De Stefani D, Mammucari C. The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function. Cell Death Dis. 2024 Jan 17;15(1):58. doi: 10.1038/s41419-024-06426-x. PMID: 38233399; PMCID: PMC10794173
  3. De Mario A, Tosatto A, Hill JM, Kriston-Vizi J, Ketteler R, Vecellio Reane D, Cortopassi G, Szabadkai G, Rizzuto R, Mammucari C. Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter. Cell Rep. 2021 Jun 22;35(12):109275. doi: 10.1016/j.celrep.2021.109275. PMID: 34161774; PMCID: PMC8242467
  4. Di Marco G, Vallese F, Jourde B, Bergsdorf C, Sturlese M, De Mario A, Techer- Etienne V, Haasen D, Oberhauser B, Schleeger S, Minetti G, Moro S, Rizzuto R, De Stefani D, Fornaro M, Mammucari C. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. doi: 10.1016/j.celrep.2020.01.081. PMID: 32075766; PMCID: PMC7034061
  5. Gherardi G, Nogara L, Ciciliot S, Fadini GP, Blaauw B, Braghetta P, Bonaldo P, De Stefani D, Rizzuto R, Mammucari C. Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference. Cell Death Differ. 2019 Jan;26(2):362-381. doi: 10.1038/s41418-018-0191-7. Epub 2018 Sep 19. PMID: 30232375; PMCID: PMC6329801

  Lorenzo Marcucci

lorenzo.marcucci@unipd.it

Pubblicazioni:

  1. Marcucci L*, Nogara L, Canato M, Germinario E, Raffaello A, Carraro M, Bernardi P, Pietrangelo L, Boncompagni S, Protasi F, Paolocci N, Reggiani C. Mitochondria can substitute for parvalbumin to lower cytosolic calcium levels in the murine fast skeletal muscle. Acta Physiol (Oxf). 2024 Sep;240(9):e14208. doi: 10.1111/apha.14208. Epub 2024 Jul 30. PMID: 39077881
  2. Spadoni S, Todros S, Reggiani C, Marcucci L (co-last), Pavan PG. The role of the extracellular matrix in the reduction of lateral force transmission in muscle bundles: A finite element analysis. Comput Biol Med. 2024 Jun;175:108488. doi: 10.1016/j.compbiomed.2024.108488. Epub 2024 Apr 17. PMID: 38653066
  3. Marcucci L*, Michelucci A, Reggiani C. Cytosolic Ca2+gradients and mitochondrial Ca2+ uptake in resting muscle fibers: A model analysis. Biophys Rep (N Y). 2023 Jul 17;3(3):100117. doi: 10.1016/j.bpr.2023.100117. PMID: 37576797; PMCID: PMC10412765
  4. Brunello E, Marcucci L, Irving M, Fusi L. Activation of skeletal muscle is controlled by a dual-filament mechano-sensing mechanism. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2302837120. doi: 10.1073/pnas.2302837120. Epub 2023 May 22. PMID: 37216507; PMCID: PMC10235942
  5. Marcucci L*. Muscle Mechanics and Thick Filament Activation: An Emerging Two- Way Interaction for the Vertebrate Striated Muscle Fine Regulation. Int J Mol Sci. 2023 Mar 27;24(7):6265. doi: 10.3390/ijms24076265. PMID: 37047237; PMCID: PMC10094676

  Oriano Marin

oriano.marin@unipd.it

Pubblicazioni:

  1. Tonolo F, Coletta S, Fiorese F, Grinzato A, Albanesi M, Folda A, Ferro S, De Mario A, Piazza I, Mammucari C, Arrigoni G, Marin O, Cestonaro G, Nataloni L, Costanzo E, Lodovichi C, Rigobello MP, de Bernard M. Sunflower seed-derived bioactive peptides show antioxidant and anti-inflammatory activity: From in silico simulation to the animal model. Food Chem. 2024 May 1;439:138124. doi: 10.1016/j.foodchem.2023.138124
  2. Scalcon V, Fiorese F, Albanesi M, Folda A, Betti G, Bellamio M, Feller E, Lodovichi C, Arrigoni G, Marin O, Rigobello MP. By-Products Valorization: Peptide Fractions from Milk Permeate Exert Antioxidant Activity in Cellular and In Vivo Models. Antioxidants (Basel). 2024 Oct 10;13(10):1221. doi: 10.3390/antiox13101221
  3. Biasiolo A, Sandre M, Ferro S, Quarta S, Ruvoletto M, Villano G, Turato C, Guido M, Marin O, Pontisso P. Epitope-Specific Anti-SerpinB3 Antibodies for SerpinB3 Recognition and Biological Activity Inhibition. Biomolecules. 2023 Apr 25;13(5):739. doi: 10.3390/biom13050739
  4. Marchesan E, Nardin A, Mauri S, Bernardo G, Chander V, Di Paola S, Chinellato M, von Stockum S, Chakraborty J, Herkenne S, Basso V, Schrepfer E, Marin O, Cendron L, Medina DL, Scorrano L, Ziviani E. Activation of Ca2+ phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies. Cell Death Differ. 2024 Feb;31(2):217-238. doi: 10.1038/s41418-023-01251-9
  5. Cross EM, Marin O, Ariawan D, Aragão D, Cozza G, Di Iorio E, Forwood JK, Alvisi G. Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44. FEBS Lett. 2024 Jan;598(2):199-209. doi: 10.1002/1873-3468.14797

  Letizia Mariotti

letizia.mariotti@cnr.it

Pubblicazioni:

  1. 2023 Nature Communication. Lia, Sansevero, Chiavegato, Sbrissa, Pendin, Mariotti, Pozzan, Berardi, Carmignoto, Fasolato, Zonta. Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease
  2. 2019 Current Biology. *Masullo, *Mariotti, Alexandre, Freire-Pritchett, Boulanger, Tripodi. Genetically defined functional modules for spatial orienting in the mouse superior colliculus
  3. 2019 Neuron. Mariotti, Tripodi. Looking at synaptic specificity from a different angle
  4. 2018 Nature Communications. Mariotti, Losi, Lia, Melone, Chiavegato, G.mez-Gonzalo, Sessolo, Bovetti, Forli, Zonta, Requie, Marcon, Pugliese, Viollet, Bettler, Fellin, Conti, Carmignoto. Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes
  5. 2017 Cell. Ciabatti, Gonz.lez-Rueda, Mariotti, Morgese, Tripodi. Life-long genetic and functional access to neural circuits using self-inactivating rabies virus

  Ionica Masgras

ionica.masgras@unipd.it

Pubblicazioni:

  1. Ciscato F, Masgras I, Gori A, Fantuz M, Bergamaschi G, Komarov D, La Spina M, Ghasemi- Firouzabadi S, Pizzi M, Dei Tos AP, Chiara F, Carrer A, Rasola A. The Use of Hexokinase 2- Displacing Peptides as an Anti-Neoplastic Approach for Malignant Peripheral Nerve Sheath Tumors. Cells. 2024 Jul 8;13(13):1162
  2. Masgras I, Cannino G, Ciscato F, Sanchez-Martin C, Darvishi FB, Scantamburlo F, Pizzi M, Menga A, Fregona D, Castegna A, Rasola A. Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3. Cell Death Differ. 2022 Oct;29(10):1996- 2008
  3. Masgras I, Laquatra C, Cannino G, Serapian SA, Colombo G, Rasola A. The molecular chaperone TRAP1 in cancer: From the basics of biology to pharmacological targeting. Semin Cancer Biol. 2021 Jul 6:S1044-579X(21)00196-6
  4. Laquatra C, Sanchez-Martin C, Dinarello A, Cannino G, Minervini G, Moroni E, Schiavone M, Tosatto S, Argenton F, Colombo G, Bernardi P, Masgras I*, Rasola A. HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia. Cell Death Dis. 2021 May 1;12(5):434
  5. Ciscato F, Filadi R, Masgras I, Pizzi M, Marin O, Damiano N, Pizzo P, Gori A, Frezzato F, Chiara F, Trentin L, Bernardi P, Rasola A. Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca2+ -dependent death of cancer cells. EMBO Rep. 2020;21(7):e49117. * corresponding author

  Denis Dominique Martinvalet

denis.martinvalet@unipd.it

  Jamie McPhee

j.s.mcphee@mmu.ac.uk

  Giovanni Minervini

giovanni.minervini@unipd.it

Pubblicazioni:

  1. Del Conte A, et al. RING 4.0: faster residue interaction networks with novel interaction types across over 35,000 different chemical structures. Nucleic Acids Res. 2024 Jul 5;52(W1):W306-W312. doi: 10.1093/nar/gkae337
  2. Inciardi I, et al. Catechol-induced covalent modifications modulate the aggregation tendency of α- synuclein: An in-solution and in-silico study. Biofactors. 2025 Jan-Feb;51(1):e2086. doi: 10.1002/biof.2086
  3. Bellanda M, et al. A PDZ scaffolding/CaM-mediated pathway in Cryptochrome signaling. Protein Sci. 2024 Mar;33(3):e4914. doi: 10.1002/pro.4914
  4. Del Conte A, et al. RING-PyMOL: residue interaction networks of structural ensembles and molecular dynamics. Bioinformatics. 2023 May 4;39(5):btad260. doi: 10.1093/bioinformatics/btad260
  5. Camagni GF, et al. Structural Characterization of Hypoxia Inducible Factor α-Prolyl Hydroxylase Domain 2 Interaction through MD Simulations. Int J Mol Sci. 2023 Mar 1;24(5):4710. doi: 10.3390/ijms24054710

  Barbara Molon

barbara.molon@unipd.it

Pubblicazioni:

  1. Angioni R, Bonfanti M, Caporale N, Sánchez-Rodríguez R, Munari F, Savino A, Pasqualato S, Buratto D, Pagani I, Bertoldi N, Zanon C, Ferrari P, Ricciardelli E, Putaggio C, Ghezzi S, Elli F, Rotta L, Scardua A, Weber J, Cecatiello V, Iorio F, Zonta F, Cattelan AM, Vicenzi E, Vannini A, Molon B, Villa CE, Viola A, Testa G. RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity. Cell Rep Med. 2023 Nov 21;4(11):101266. doi: 10.1016/j.xcrm.2023.101266. Epub 2023 Nov 8
  2. Sánchez-Rodríguez R., Tezze C.,. Agnellini A., Angioni A., Venegas F., Cioccarelli C., Munari F., Bertoldi N., Canton M., Desbats M.A., Salviati L., Gissi R., Castegna A., Soriano M.E., Sandri M., Scorrano L., Viola A, Molon B. OPA1 drives macrophage metabolism and functional commitment via p65 signalling., Cell Death Differ. 2023 Mar;30(3):742-752. doi: 10.1038/s41418-022-01076-y. Epub 2022 Oct 28
  3. Cioccarelli C, Sánchez-Rodríguez R, Angioni R, Venegas FC, Bertoldi N, Munari F, Cattelan A, Molon B, Viola A. IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis. Front Immunol. 2021 Dec 7;12:781352. Doi: 10.3389/fimmu.2021.781352
  4. Calì B, Agnellini AHR, Cioccarelli C, Sanchez-Rodriguez R, Predonzani A, Toffolo GI, Viola A, Bronte V, Arrigoni G, Zonta F, Albertoni L, Mescoli C, Marigo I, Molon B. GM-CSF Nitration Is a New Driver of Myeloid Suppressor Cell Activity in Tumors. Front Immunol. 2021 Oct 5;12:718098. doi: 10.3389/fimmu.2021.718098
  5. Angioni R, Sánchez-Rodríguez R, Munari F, Bertoldi N, Arcidiacono D, Cavinato S, Marturano D, Zaramella A, Realdon S, Cattelan A, Viola A, Molon B*. Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients. Cell Death Dis. 2020 Nov 6;11(11):957. doi: 10.1038/s41419-020-03151-z.

  Marco Mongillo

marco.mongillo@unipd.it

  Marta Murgia

marta.murgia@unipd.it

  Marco Narici

marco.narici@unipd.it

Pubblicazioni:

  1. Franchi MV, Candia J, Sarto F, Sirago G, Valli G, Paganini M, Hartnell L, Giacomello E, Toniolo L, Monti E, Nogara L, Moro T, Paoli A, Murgia M, Brocca L, Pellegrino MA, Grassi B, Bottinelli R, De Vito G, Ferrucci L, Narici MV. Previous short-term disuse dictates muscle gene expression and physiological adaptations to subsequent resistance exercise. J Physiol. 2025 Jan 10. doi: 10.1113/JP287003
  2. Motanova E, Pirazzini M, Negro S, Rossetto O, Narici M. Impact of ageing and disuse on neuromuscular junction and mitochondrial function and morphology: Current evidence and controversies. Ageing Res Rev. 2024 Dec;102:102586. doi: 10.1016/j.arr.2024.102586
  3. Sarto F, Franchi MV, McPhee JS, Stashuk DW, Paganini M, Monti E, Rossi M, Sirago G, Zampieri S, Motanova ES, Valli G, Moro T, Paoli A, Bottinelli R, Pellegrino MA, De Vito G, Blau HM, Narici MV. Neuromuscular impairment at different stages of human sarcopenia. J Cachexia Sarcopenia Muscle. 2024 Oct;15(5):1797-1810. doi: 10.1002/jcsm.13531
  4. Sarto F, Stashuk DW, Franchi MV, Monti E, Zampieri S, Valli G, Sirago G, Candia J, Hartnell LM, Paganini M, McPhee JS, De Vito G, Ferrucci L, Reggiani C, Narici MV. Effects of short-term unloading and active recovery on human motor unit properties, neuromuscular junction transmission and transcriptomic profile. J Physiol. 2022 Nov;600(21):4731-4751. doi: 10.1113/JP283381
  5. Monti E, Reggiani C, Franchi MV, Toniolo L, Sandri M, Armani A, Zampieri S, Giacomello E, Sarto F, Sirago G, Murgia M, Nogara L, Marcucci L, Ciciliot S, Šimunic B, Pišot R, Narici MV. Neuromuscular junction instability and altered intracellular calcium handling as early determinants of force loss during unloading in humans. J Physiol. 2021 Jun;599(12):3037-3061. doi: 10.1113/JP281365.

  Maurizio Onisto

maurizio.onisto@unipd.it

Pubblicazioni:

  1. Masola V, Zaza G, Bellin G, Dall’Olmo L, Granata S, Vischini G, Secchi MF, Lupo A, Gambaro G, Onisto M. Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury. FASEB J. 2018 Feb;32(2):742-756. doi: 10.1096/fj.201700597R
  2. Masola V , Zaza G , Gambaro G, Franchi M , Onisto M. Heparanase in Extracellular Matrix (ECM) remodeling during tumor progression: molecular aspects and therapeutic options. Seminars Cancer Biology May 2020, 62, 86-98. doi.org/10.1016/j.semcancer.2019.07.014
  3. Karamanos NK, Theocharis AD, Piperigkou Z, Manou D, Passi A, Skandalis SS, Vynios DH, Orian-Rousseau V, Ricard-Blum S, Schmelzer CEH, Duca L, Durbeej M, Afratis NA, Troeberg L, Franchi M, Masola V, Onisto M. A guide to the composition and functions of the extracellular matrix. FEBS J. 2021 Dec;288(24):6850-6912. doi: 10.1111/febs.15776
  4. Masola V, Franchi M, Zaza G, Atsina FM, Gambaro G, Onisto M. Heparanase regulates EMT and cancer stem cell properties in prostate tumors. Front Oncol. 2022 Jul 27;12:918419. doi: 10.3389/fonc.2022.918419
  5. Masola V, Greco N, Tozzo P, Caenazzo L, Onisto M. The role of SPATA2 in TNF signaling, cancer, and spermatogenesis. Cell Death Dis. 2022 Nov 19;13(11):977. doi: 10.1038/s41419-022-05432-1

  Giorgia Pallafacchina

giorgia.pallafacchina@unipd.it

Pubblicazioni:

  1. Caroccia B, Seccia TM, Pallafacchina G, Piazza M, Caputo I, Zamberlan S, Rizzuto R, Rossi GP. Aldosterone Biosynthesis Is Potently Stimulated by Perfluoroalkyl Acids: A Link between Common Environmental Pollutants and Arterial Hypertension. Int J Mol Sci. 2023 May 27;24(11):9376. doi:10.3390/ijms24119376. PMID: 37298327; PMCID: PMC10253916
  2. Sánchez-Vázquez VH, Martínez-Martínez E, Gallegos-Gómez ML, Arias JM,Pallafacchina G, Rizzuto R, Guerrero-Hernández A. Heterogeneity of the endoplasmic reticulum Ca 2+ store determines colocalization with mitochondria. Cell Calcium. 2023 Jan;109:102688. doi:10.1016/j.ceca.2022.102688. Epub 2022 Dec 11. PMID: 36538845
  3. Salizzato V, Zanin S, Borgo C, Lidron E, Salvi M, Rizzuto R, Pallafacchina G, Donella- Deana A. Protein kinase CK2 subunits exert specific and coordinated functions in skeletal muscle differentiation and fusogenic activity. FASEB J. 2019 Oct;33(10):10648-10667. doi:10.1096/fj.201801833RR. Epub 2019 Jul 3. PMID:31268746; PMCID: PMC6766657
  4. Zanin S, Lidron E, Rizzuto R, Pallafacchina G. Methods to Measure Intracellular Ca 2+ Concentration Using Ca 2+ -Sensitive Dyes. Methods Mol Biol. 2019;1925:43-58. doi: 10.1007/978-1-4939-9018-4_4. PMID:30674015
  5. Gregianin E, Pallafacchina G, Zanin S, Crippa V, Rusmini P, Poletti A, Fang M, Li Z, Diano L, Petrucci A, Lispi L, Cavallaro T, Fabrizi GM, Muglia M, Boaretto F, Vettori A, Rizzuto R, Mostacciuolo ML, Vazza G. Loss-of-function mutations in the SIGMAR1 gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+ signalling. Hum Mol Genet. 2016 Sep 1;25(17):3741-3753. doi: 10.1093/hmg/ddw220. PMID: 27402882.

  Nazareno Paolocci

nazareno.paolocci@unipd.it

  Emanuele Papini

emanuele.papini@unipd.it

Pubblicazioni:

  1. The Topology of Poly(2-methyl-2-oxazine) Shells on Nanoparticles Determines Their Interaction with Serum and Uptake by Immune Cells. Morbidelli M, Romio M, Chandorkar Y, Gogos A, Hirsch C, Kolrosova B, Trachsel L, Lorandi F, Badocco D, Pastore P, Arrigoni G, Franchin C, Tavano R, Hoogenboom R, Papini E*, Benetti EM. Biomacromolecules. 2025 Jan 13;26(1):556-566. doi: 10.1021/acs.biomac.4c01340.
  2. Essential protocols for decoding the composition and the functional effects of the nanoparticle protein corona. Morbidelli M, PapiniE, Tavano R*. Front. Nanotechnol., 2024, 6. doi.org/10.3389
  3. Nanoparticles Based on Cross-Linked Poly(Lipoic Acid) Protect Macrophages and Cardiomyocytes from Oxidative Stress and Ischemia Reperfusion Injury.Bellini C, Antonucci S, Morillas-Becerril L, Scarpa S, Tavano R, Mancin F, Di Lisa F, Papini E*. Antioxidants (Basel). 2022 May 5;11(5):907.
  4. Antioxidants (Basel). 2022 May 5;11(5):907. doi: 10.3390/antiox11050907. Poly(lipoic acid)-Based Nanoparticles as Self-Organized, Biocompatible, and Corona-Free Nanovectors. Trzciński JW, Morillas-Becerril L, Scarpa S, Tannorella M, Muraca F, Rastrelli F, Castellani C, Fedrigo M, Angelini A, Tavano R*, Papini E, Mancin F. Biomacromolecules. 2021 Feb 8;22(2):467-480. doi: 10.1021/acs.biomac.0c01321.
  5. Opsonins and Dysopsonins of Nanoparticles: Facts, Concepts, and Methodological Guidelines. Papini E*, Tavano R, Mancin F. Front Immunol. 2020 Oct 12;11:567365. doi: 10.3389/fimmu.2020.567365

  Diana Pendin

diana.pendin@unipd.it

Pubblicazioni:

  1. García Casas P, Rossini M, et al., Paola Pizzo*, Riccardo Filadi*. (*corresponding author) (2024) Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible chemogenetic reporters. Nature Communications, 15(1):9775
  2. Rossi A., Rigotto G., Valente G., Giorgio V., Basso E., Filadi R. and Pizzo P. (2020). Defective mitochondrial pyruvate flux affects cell bioenergetics in Alzheimer’s disease related models. Cell Reports, 30(7):2332-2348.e10
  3. Fedeli C., Filadi R., Rossi A., Mammucari C. and Pizzo P. (2019) PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca 2+ homeostasis. Autophagy, 20:1-19
  4. Theurey P., Connolly N.M., Fortunati I., Basso E., Lauwen S., Ferrante C., Moreira Pinho C., Joselin A., Gioran A., Bano D., Park D., Ankarcrona M., Pizzo P.* and Prehn J.H.M.* (*corresponding author) (2019)
  5. Systems biology analysis identifies impairment of mitochondrial and glycolytic metabolism in a genetic model of Alzheimer’s disease. Aging Cell, 18(3):e12924. 5. Filadi R., Greotti E., Turacchio G., Luini, A., Pozzan T., Pizzo P. (2016) Presenilin 2 modulates endoplasmic reticulum-mitochondria coupling by tuning the antagonistic effect of mitofusin 2. Cell Reports,15(10):2226-38.

  Maria Pennuto

maria.pennuto@unipd.it 

Pubblicazioni:

  1. Prakasam R, Bonadiman A, Andreotti R, Zuccaro E, Dalfovo D, Marchioretti C, Tripathy D, Petris G, Anderson EN, Migazzi A, Tosatto L, Cereseto A, Battaglioli E, Sorarù G, Lim WF, Rinaldi C, Sambataro F, Pourshafie N, Grunseich C, Romanel A, Pandey UB, Contestabile A, Ronzitti G, Basso M, Pennuto M*. 2023. LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice. Nature Comm 14:303. IF2023 17.7
  2. Marchioretti C, Zanetti G, Pirazzini M, Gherardi G, Nogara L, Andreotti R, Martini P, Marcucci L, Canato M, Nath SR, Zuccaro E, Chivet M, Mammucari C, Pacifici M, Raffaello A, Rizzuto R, Mattarei A, Desbats MA, Salviati L, Megighian A, Sorarù G, Pegoraro E, Belluzzi E, Pozzuoli A, Biz C, Ruggieri P, Romualdi C, Lieberman AP, Babu GJ, Sandri M, Blaauw B, Basso M, Pennuto M*. 2023. Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca2+ accumulation in spinobulbar muscular atrophy skeletal muscle. Nature Comm 14:602. IF2023 17.7
  3. Piol D, Tosatto L, Zuccaro E, Anderson EN, Falconieri A, Polanco MJ, Marchioretti C, Lia F, White J, Bregolin E, Minervini G, Parodi S, Salvatella X, Arrigoni G, Ballabio A, La Spada AR, Tosatto SCE, Sambataro F, Medina DL, Pandey UB, Basso M, Pennuto M*. 2023. Antagonistic effect of cyclin-dependent kinases and a calcium-dependent phosphatase on polyglutamine-expanded androgen receptor toxic gain of function. Sci. Adv. 9(1):eade1694. IF2023 14.957
  4. Turco EM, Giovenale AMG, Sireno L, Mazzoni M, Cammareri A, Marionette M, Goracci L, Di Veroli A, D'Andrea D, Marchesan E, Torres B, Bernardini L, Magnifico M, Paone A, Rinaldo S, Della Monica M, D'Arrigo S, Postorivo D, Nardone AM, Zampino G, Onesimo R, Leoni C, Caicci F, Raimondo D, Binda E, Trobiani L, De Jaco A, Tata AM, Ferrari D, Cutruzzolà F, Mazzoccoli G, Ziviani E, Pennuto M*, Vescovi A*, Rosati J*. 2022. Retinoic acid-induced 1 gene haploinsufficiency alters lipid metabolism and causes autophagy defects in Smith-Magenis syndrome. Cell Death & Disease 13:981. IF2022 9.696
  5. Migazzi A#, Scaramuzzino C#, Tripathy D, Hernández IH, Virlogeux A, Zuccato C, Caricasole A, Ratovitski T, Ross CA, Pandey UB, Lucas JJ, Saudou F*, Pennuto M*, Basso M*. 2021. Huntingtin-mediated axonal transport requires arginine methylation by PRMT6. Cell Rep 35:108980. IF2021 9.995

  Damiano Piovesan

damiano.piovesan@unipd.it 

Pubblicazioni:

  1. Piovesan, Damiano; Zago, Davide; Joshi, Parnal; De Paolis Kaluza, M Clara; Mehdiabadi, Mahta; Ramola, Rashika; Monzon, Alexander Miguel; Reade, Walter; Friedberg, Iddo; Radivojac, Predrag CAFA-evaluator: a Python tool for benchmarking ontological classification methods 2024, Bioinformatics Advances, 4,1,vbae043
  2. Aspromonte, Maria Cristina; Nugnes, Maria Victoria; Quaglia, Federica; Bouharoua, Adel; Tosatto, Silvio CE; Piovesan, Damiano DisProt in 2024: improving function annotation of intrinsically disordered proteins 2024, Nucleic Acids Research, 52,D1,D434-D441
  3. Del Conte, Alessio; Camagni, Giorgia F; Clementel, Damiano; Minervini, Giovanni; Monzon, Alexander Miguel; Ferrari, Carlo; Piovesan, Damiano; Tosatto, Silvio CE RING 4.0: faster residue interaction networks with novel interaction types across over 35,000 different chemical structures 2024, Nucleic Acids Research, gkae337
  4. Piovesan, Damiano; Del Conte, Alessio; Mehdiabadi, Mahta; Aspromonte, Maria Cristina; Blum, Matthias; Tesei, Giulio; von Bülow, Sören; Lindorff-Larsen, Kresten; Tosatto, Silvio CE MOBIDB in 2025: integrating ensemble properties and function annotations for intrinsically disordered proteins 2025, Nucleic Acids Research, 53,D1,D495-D503
  5. Blum, Matthias; Andreeva, Antonina; Florentino, Laise Cavalcanti; Chuguransky, Sara Rocio; Grego, Tiago; Hobbs, Emma; Pinto, Beatriz Lazaro; Orr, Ailsa; Paysan-Lafosse, Typhaine; Ponamareva, Irina InterPro: the protein sequence classification resource in 2025 2025, Nucleic Acids Research, 53,D1,D444-D456

  Marco Pirazzini

marco.pirazzini@unipd.it

Pubblicazioni:

  1. Machicoane M, Tonellato M, Zainotto M, Onillon P, Stazi M, Corso MD, Megighian A, Rossetto O, Le Doussal JM, Pirazzini M. Excitation-contraction coupling inhibitors potentiate the actions of botulinum neurotoxin type A at the neuromuscular junction. Br J Pharmacol. 2025 Feb;182(3):564- 580. doi: 10.1111/bph.17367. Epub 2024 Oct 10. PMID: 39389783
  2. Fabris F, Megighian A, Rossetto O, Simonato M, Schiavo G, Pirazzini M, Montecucco C. Local Tetanus Begins with a Neuromuscular Junction Paralysis around the Site of Tetanus Neurotoxin Release due to Cleavage of the Vesicle-Associated Membrane Protein. Am J Pathol. 2024 Sep;194(9):1752-1763. doi:10.1016/j.ajpath.2024.05.009. Epub 2024 Jun 15. PMID: 38885925
  3. Fabris F, Varani S, Tonellato M, Matak I, Šoštarić P, Meglić P, Caleo M, Megighian A, Rossetto O, Montecucco C, Pirazzini M. Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus. JCI Insight. 2023 Jun 8;8(11):e166978. doi: 10.1172/jci.insight.166978. PMID: 37159261; PMCID: PMC10393225
  4. Marchioretti C, Zanetti G, Pirazzini M, Gherardi G, Nogara L, Andreotti R, Martini P, Marcucci L, Canato M, Nath SR, Zuccaro E, Chivet M, Mammucari C, Pacifici M, Raffaello A, Rizzuto R, Mattarei A, Desbats MA, Salviati L, Megighian A, Sorarù G, Pegoraro E, Belluzzi E, Pozzuoli A, Biz C, Ruggieri P, Romualdi C, Lieberman AP, Babu GJ, Sandri M, Blaauw B, Basso M, Pennuto M. Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca 2+ accumulation in spinobulbar muscular atrophy skeletal muscle. Nat Commun. 2023 Feb 6;14(1):602. doi:10.1038/s41467-023-36185-w. PMID: 36746942; PMCID: PMC9902403
  5. Pirazzini M, Grinzato A, Corti D, Barbieri S, Leka O, Vallese F, Tonellato M, Silacci-Fregni C, Piccoli L, Kandiah E, Schiavo G, Zanotti G, Lanzavecchia A, Montecucco C. Exceptionally potent human monoclonal antibodies are effective for prophylaxis and treatment of tetanus in mice. J Clin Invest. 2021 Nov 15;131(22):e151676. doi: 10.1172/JCI151676. PMID: 34618682; PMCID: PMC8592554.

  Anna Raffaello

anna.raffaello@unipd.it

Pubblicazioni:

  1. D’Angelo, Sanchez-Vazquez VH, Cartes-Saavedra B, Vecellio Reane D, Ghirardo G, Cupo RR, Delgado de la Herran H, Shorter J, Wevers RA, Wortmann SB, Perocchi F, Rizzuto R*, Raffaello A*, Hajnóczky G. Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB. Nature Comm. Accepted.
  2. Feno S, Munari F, Reane DV, Gissi R, Hoang DH, Castegna A, Chazaud B, Viola A, Rizzuto R, Raffaello A. The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration. Sci Signal. 2021 Nov 2;14(707):eabf3838. PMID: 34726954.
  3. Vecellio Reane D, Vallese F, Checchetto V, Acquasaliente L, Butera G, De Filippis V, Szabò I, Zanotti G, Rizzuto R, Raffaello A. A MICU1 Splice Variant Confers High Sensitivity to the Mitochondrial Ca2+ Uptake Machinery of Skeletal Muscle. Mol Cell. 2016 Nov 17;64(4):760-773. PMID: 27818145.
  4. Raffaello A, De Stefani D, Sabbadin D, Teardo E, Merli G, Picard A, Checchetto V, Moro S, Szabò I, Rizzuto R. The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. EMBO J. 2013 Aug 28;32(17):2362-76. PMID: 23900286.
  5. De Stefani D, Raffaello A*, Teardo E, Szabò I, Rizzuto R. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature. 2011 Jun 19;476(7360):336-40. PMID: 21685888. (*co-first author)

  Andrea Rasola

andrea.rasola@unipd.it

Pubblicazioni:

  1. "Ciscato F, Filadi R, Masgras I, Pizzi M, Marin O, Damiano N, Pizzo P, Gori A, Frezzato F, Trentin L, Bernardi P, Rasola A* (2020) Selective displacement of Hexokinase 2 from mitochondria-endoplasmic reticulum contact sites prompts Ca2+-dependent death of cancer cells. EMBO Rep 21:e49117
  2. Sanchez-Martin C, Moroni E, Ferraro M, Laquatra C, Cannino G, Masgras I, Negro A, Quadrelli P, Rasola A*, Colombo G (2020) Rational design of allosteric and selective inhibitors of the molecular chaperone TRAP1 Cell Rep 31:107531
  3. Masgras I, Cannino G, Ciscato F, Sanchez-Martin C, Darvishi FB, Scantamburlo F, Pizzi M, Menga A, Fregona D, Castegna A, Rasola A* (2022) Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3. Cell Death Differ 29:1996-2008
  4. Cannino G, Urbani A, Gaspari M, Varano M, Negro A, Filippi A, Ciscato F, Masgras I, Gerle C, Tibaldi E, Brunati AM, Colombo G, Lippe G, Bernardi P, Rasola A* (2022) The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation. Cell Death Differ 29:2335-2346
  5. Laquatra C, Magro A, Guarra F, Lambrughi M, Bacchin M, Fracasso G, Ferrone L, La Spina M, Moroni E, Papaleo E, Colombo G, Rasola A* (2025) Point mutations of the mitochondrial chaperone TRAP1 affect its functions and pro-neoplastic activity. Cell Death Dis (in press) * corresponding author"

  Michela Rigoni

michela.rigoni@unipd.it

Pubblicazioni:

  1. Negro S, Lauria F, Stazi M, Tebaldi T, D'Este G, Pirazzini M, Megighian A, Lessi F, Mazzanti CM, Sales G, Romualdi C, Fillo S, Lista F, Sleigh JN, Tosolini AP, Schiavo G, Viero G, Rigoni M. Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor. Acta Neuropathol Commun. 2022 Dec 25;10(1):189.
  2. Stazi M, Negro S, Megighian A, D'Este G, Solimena M, Jockers R, Lista F, Montecucco C, Rigoni M. Melatonin promotes regeneration of injured motor axons via MT1 receptors. J Pineal Res. 2021 Jan;70(1):e12695.
  3. Rigoni M and Negro S. Signals orchestrating peripheral nerve repair. Cells 2020, 9, 1768.
  4. Negro, S., Lessi, F., Duregotti, E., Aretini, P., La Ferla, M., Franceschi, S., Menicagli, M., Bergamin, E., Radice, E., Thelen, M., Megighian, A., Pirazzini, M., Mazzanti, C.M., Rigoni, M., Montecucco, C. (2017) CXCL12α/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals. EMBO Molecular Medicine, 9 (8), pp. 1000-1010.
  5. Duregotti E, Negro S, Scorzeto M, Zornetta I, Dickinson BC, Chang CJ, Montecucco C, Rigoni M (2015) Mitochondrial alarmins released by degenerating motor axon terminals activate perisynaptic Schwann cells. Proc Natl Acad Sci U S A 2015 Feb 3;112(5):E497-505.

  Rosario Rizzuto

rosario.rizzuto@unipd.it

Pubblicazioni:

  1. S. Feno, F. Munari, D.V. Reane, R. Gissi, D.H. Hoang, A. Castegna, B. Chazaud, A. Viola*, R.Rizzuto*, A. Raffaello* (2021). The dominant negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration. Sci. Signal. 14(707):eabf3838
  2. A. Paggio, V. Checchetto, A. Campo, R. Menabò, G. Di Marco, F. Di Lisa, I. Szabo, R. Rizzuto*, D. De Stefani* (2019). Identification of an ATP-sensitive potassium channel in mitochondria. Nature 572:609-613
  3. M. Patron, V. Checchetto, A. Raffaello, E. Teardo, D. Vecellio Reane, M. Mantoan, V. Granatiero, I. Szabò, D. De Stefani* and R. Rizzuto* (2014) MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity. Mol. Cell 53:726- 737
  4. A. Raffaello, D. De Stefani, D. Sabbadin, E. Teardo, G. Merli, A. Picard, V. Checchetto, S. Moro, I. Szabò, R. Rizzuto* (2013) The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. EMBO J. 32:2362-76
  5. R. Rizzuto*, D. De Stefani, A. Raffaello, C. Mammucari (2012) Mitochondria as sensors and regulators of calcium signalling. Nat. Rev. Mol. Cell Biol. 9, 566-578. *corresponding author

  Vanina Natalia Romanello

vanina.romanello@unipd.it

Pubblicazioni:

  1. Scalabrin M, Turco E, Nogara L, Gherardi G, Trani G, Negro S, Franco Romero A, Jaspers Y, Baschiera E, De Cegli R, Del Prete E, Cali T, Blaauw B, Salviati L, Rigoni M, Mammucari C, Caspar-Bauguil S, Moro C, Sandri M, Kemp S and Romanello V* Alterations in peroxisomal-mitochondrial interplay in skeletal muscle accelerates muscle dysfunction bioRxiv 2024.04.25.591056; doi: https://doi.org/10.1101/2024.04.25.591056 Under revision in Nat Comm * corresponding
  2. Boardman NT, Trani G, Scalabrin M, Romanello V*, Wüst RCI. Intra-cellular to inter- organ mitochondrial communication in striated muscle in health and disease. Endocr Rev. 2023 Feb 26. * corresponding, IF:25,26
  3. Romanello V*, Sandri M. Implications of mitochondrial fusion and fission in skeletal muscle mass and health. Semin Cell Dev Biol. 2022 Feb 12:S1084-9521(22)00050-7. * corresponding, IF:7,49
  4. Sartori R, Romanello V* & Sandri, M. Mechanisms of muscle atrophy and hypertrophy: implications in health and disease. Nat Commun 12, 330 (2021). * corresponding, IF:17,69
  5. Romanello V*. FGF21: a promising therapeutic agent for alcoholic cardiomyopathy?†. J Pathol. 2021 Jul;254(3):213-215

  Maria Ruzzene

maria.ruzzene@unipd.it

Pubblicazioni:

  1. Quezada Meza CP, Salizzato V, Calistri E, Basso M, Zavatti M, Marmiroli S, Salvi M, Carter BZ, Donella-Deana A, Borgo C, Ruzzene M. Critical role of protein kinase CK2 in chronic myeloid leukemia cells harboring the T315I BCR::ABL1 mutation. Int J Biol Macromol. 2025 Jan;286:138305. doi: 10.1016/j.ijbiomac.2024.138305
  2. Di Lorenzo G, Iavarone F, Maddaluno M, Plata-Gómez AB, Aureli S, Quezada Meza CP, Cinque L, Palma A, Reggio A, Cirillo C, Sacco F, Stolz A, Napolitano G, Marin O, Pinna LA, Ruzzene M, Limongelli V, Efeyan A, Grumati P, Settembre C. Phosphorylation of FAM134C by CK2 controls starvation induced ER-phagy. Sci Adv 2022 Sep 2;8(35):eabo1215. doi: 10.1126/sciadv.abo1215
  3. Borgo C, D'Amore C, Sarno S, Salvi M, Ruzzene M. Protein kinase CK2: a potential therapeutic target for diverse human diseases. Signal Transduct Target Ther. 2021 May 17;6(1):183. doi: 10.1038/s41392-021-00567-7. PMID: 33994545; PMCID: PMC8126563
  4. Zonta F, Borgo C, Quezada Meza CP, Masgras I, Rasola A, Salvi M, Pinna LA, Ruzzene M Contribution of the CK2 Catalytic Isoforms α and α' to the Glycolytic Phenotype of Tumor Cells.. Cells. 2021 Jan 18;10(1):181. doi: 10.3390/cells10010181
  5. Di Maira G, Gentilini A, Pastore M, Caligiuri A, Piombanti B, Raggi C, Rovida E, Lewinska M, Andersen JB, Borgo C, Salvi M, Ottaviani D, Ruzzene M, Marra F. The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cells. Oncogenesis. 2019 Oct 22;8(11):61. doi:10.1038/s41389-019-0171-x.

  Mauro Salvi

mauro.salvi@unipd.it

Pubblicazioni:

  1. TSUKASA O., BORGO C., BOSELLO TRAVAIN V., PEDEMONTE N. SALVI M.* Targeting protein ubiquitination in Cystic Fibrosis. Where we stand? CMLS, 81(1):271 (2024).
  2. D’ AMORE C., BORGO C, BOSELLO TRAVAIN V., SALVI M. KDM2A and KDM3B as potential targets for the rescue of F508del-CFTR IJMS, 23(17):9612 (2022).
  3. SALVI M., BORGO C, PINNA L.A., RUZZENE M. Targeting CK2 in cancer: a valuable strategy or a waste of time? Cell death discovery, 7(1):325 (2021).
  4. BORGO C., D’AMORE C., CESARO, L., SARNO S., PINNA L.A.P. RUZZENE M., SALVI M. How can a traffic light properly work if it is always green? The paradox of “CK2 signalling ” Critical Reviews in Biochemistry and Molecular Biology, 56(4):321-359 (2021)
  5. D’ AMORE C., BORGO C, SALVI M. A mutational approach to dissect the functional role of the putative CFTR “PTM code” Journal of Cystic Fibrosis, 20(5):891-894 (2021).

  Marco Sandri

marco.sandri@unipd.it

Pubblicazioni:

  1. Calderan, Cristina, Sorrentino, Ugo, Persano, Luca, Trevisson, Eva, Sartori, Geppo, Salviati, Leonardo, Desbats, Maria Andrea (2024). A yeast based assay establishes the pathogenicity of novel missense ACTA2 variants associated with aortic aneurysms. EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 32, p. 804-812, ISSN: 1018-4813, doi: 10.1038/s41431-024-01591-1
  2. Doni D., Cavallari E., Noguera M. E., Gentili H. G., Cavion F., Parisi G., Fornasari M. S., Sartori G., Santos J., Bellanda M., Carbonera D., Costantini P., Bortolus M. (2024). Searching for Frataxin Function: Exploring the Analogy with Nqo15, the Frataxin-like Protein of Respiratory Complex I from Thermus thermophilus. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, 1912, ISSN: 1422-0067, doi: 10.3390/ijms25031912
  3. Ancora, Caterina, Marchi, Marco, Bonardi, Claudia Maria, Sartori, Geppo, Lopreiato, Raffaele, Zuccarello, Daniela, D'Errico, Ignazio, Nosadini, Margherita, Sartori, Stefano, Boniver, Clementina, Toldo, Irene, Salviati, Leonardo (2023). Electroclinical features in two novel STRADA patients and a functional yeast assay for the validation of missense STRADA mutations. PEDIATRIC NEUROLOGY, vol. 148, p. 152-156, ISSN: 0887-8994, doi: 10.1016/j.pediatrneurol.2023.08.018
  4. Davide Doni, Federica Cavion, Marco Bortolus, Elisa Baschiera, Silvia Muccioli, Giulia Tombesi, Federica D'Ettorre, Daniele Ottaviani, Elena Marchesan, Luigi Leanza, Elisa Greggio, Elena Ziviani, Antonella Russo, Milena Bellin, Geppo Sartori, Donatella Carbonera, Leonardo Salviati, Paola Costantini (2023). Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain. CELL DEATH & DISEASE, vol. 14, ISSN: 2041-4889, doi: 10.1038/s41419-023-06320-y
  5. Peggion, Caterina, Massimino, Maria Lina, Pereira, Daniel, Granuzzo, Sara, Righetto, Francesca, Bortolotto, Raissa, Agostini, Jessica, Sartori, Geppo, Bertoli, Alessandro, Lopreiato, Raffaele (2023). Structural Integrity of Nucleolin Is Required to Suppress TDP-43-Mediated Cytotoxicity in Yeast and Human Cell Models. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, ISSN: 1422-0067, doi: 10.3390/ijms242417466

  Stefania Sarno

  Geppo Sartori

geppo.sartori@unipd.it

Pubblicazioni:

  1. Calderan, Cristina, Sorrentino, Ugo, Persano, Luca, Trevisson, Eva, Sartori, Geppo, Salviati, Leonardo, Desbats, Maria Andrea (2024). A yeast based assay establishes the pathogenicity of novel missense ACTA2 variants associated with aortic aneurysms. EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 32, p. 804-812, ISSN: 1018-4813, doi: 10.1038/s41431-024-01591-1
  2. Doni D., Cavallari E., Noguera M. E., Gentili H. G., Cavion F., Parisi G., Fornasari M. S., Sartori G., Santos J., Bellanda M., Carbonera D., Costantini P., Bortolus M. (2024). Searching for Frataxin Function: Exploring the Analogy with Nqo15, the Frataxin-like Protein of Respiratory Complex I from Thermus thermophilus. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25, 1912, ISSN: 1422-0067, doi: 10.3390/ijms25031912
  3. Ancora, Caterina, Marchi, Marco, Bonardi, Claudia Maria, Sartori, Geppo, Lopreiato, Raffaele, Zuccarello, Daniela, D'Errico, Ignazio, Nosadini, Margherita, Sartori, Stefano, Boniver, Clementina, Toldo, Irene, Salviati, Leonardo (2023). Electroclinical features in two novel STRADA patients and a functional yeast assay for the validation of missense STRADA mutations. PEDIATRIC NEUROLOGY, vol. 148, p. 152-156, ISSN: 0887-8994, doi: 10.1016/j.pediatrneurol.2023.08.018
  4. Davide Doni, Federica Cavion, Marco Bortolus, Elisa Baschiera, Silvia Muccioli, Giulia Tombesi, Federica D'Ettorre, Daniele Ottaviani, Elena Marchesan, Luigi Leanza, Elisa Greggio, Elena Ziviani, Antonella Russo, Milena Bellin, Geppo Sartori, Donatella Carbonera, Leonardo Salviati, Paola Costantini (2023). Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain. CELL DEATH & DISEASE, vol. 14, ISSN: 2041-4889, doi: 10.1038/s41419-023-06320-y
  5. Peggion, Caterina, Massimino, Maria Lina, Pereira, Daniel, Granuzzo, Sara, Righetto, Francesca, Bortolotto, Raissa, Agostini, Jessica, Sartori, Geppo, Bertoli, Alessandro, Lopreiato, Raffaele (2023). Structural Integrity of Nucleolin Is Required to Suppress TDP-43-Mediated Cytotoxicity in Yeast and Human Cell Models. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, ISSN: 1422-0067, doi: 10.3390/ijms242417466

  Giampietro Schiavo

giampietro.schiavo@ucl.ac.uk

Pubblicazioni:

  1. Surana S, Villarroel-Campos D, Rhymes ER, Kalyukina M, Panzi C, Novoselov SS, Fabris F, Richter S, Pirazzini M, Zanotti, Z, and Schiavo G (2024) The tyrosine phosphatases LAR and PTPRD act as receptors of the nidogen-tetanus toxin complex. EMBO J 43, 3358-3387.
  2. Sleigh JN, Mattedi F, Richter S, Ng K, Steinmark IE, Ivanova I, Daraban I, Joshi P, Annuario E, Awale S, Yahioglu G, Mitchell JC, Suhling K, Schiavo G and Vagnoni A (2024) Age-specific and compartment- dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons. Aging Cell 23, e14250.
  3. Sleigh JN, Villarroel-Campos D, Surana S, Wickenden T, Tong Y, Simkin RL, Vargas JNS, Rhymes ER, Tosolini AP, West SJ, Zhang Q, Yang X-L and Schiavo G (2023) Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice. JCI Insight 16, e157191.
  4. Lazo OM and Schiavo G (2023) Rab10 regulates the sorting of internalised TrkB to retrograde axonal transport. eLife 12, e81532.
  5. Brown A-L, Wilkins OG, Keuss MJ, Hill SE, Zanovello M, Lee WC, Bampton A, Lee FCY, Masino L, Qi YA, Bryce-Smith S, Gatt A, Hallegger M, Fagegaltier D, Phatnani H, NYGC ALS Consortium, Newcombe J, Gustavsson EK, Seddighi S, Reyes JF, Coon SL, Ramos D, Schiavo G, Fisher EMC, Raj T, Secrier M, Lashley T, Ule J, Buratti E, Humphrey J, Ward ME and Fratta P (2022). ALS/FTD risk variants in UNC13A exacerbate its cryptic splicing upon TDP-43 pathology. Nature 603, 131-137.

  Roberto Steiner

roberto.steiner@unipd.it

Pubblicazioni:

  1. Bolton R, Machlett MM, .......Steiner RA,........Owen RL, Tews I (2024) A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus. Proc Natl Acad Sci USA, 121, e2308478121. doi: 10.1073/pnas.2308478121
  2. Catapano L, Long F, Yamashita K, Nicholls RA, Steiner* RA, Murshudov GN (2023) Neutron crystallographic refinement with REFMAC5 from the CCP4 suite. Acta Crystallogr D Struct Biol. 79:1056-1070. doi: 10.1107/S2059798323008793
  3. Bui S, Gil-Guerrero S, van der Linden P, Carpentier P, Ceccarelli M, Jambrina PG, Steiner* RA (2023) Evolutionary adaptation from hydrolytic to oxygenolytic catalysis at the α/β-hydrolase fold. Chem Sci. 14:10547-10560. doi: 10.1039/d3sc03044j
  4. Mori G, Liuzzi A, Ronda L, Di Palma M, Chegkazi MS, Bui S, Garcia-Maya M, Ragazzini J, Malatesta M, Della Monica E, Rivetti C, Antin PB, Bettati S, Steiner* RA, Percudani R (2023) Cysteine Enrichment Mediates Co-Option of Uricase in Reptilian Skin and Transition to Uricotelism. Mol Biol Evol. 40:msad200. doi: 10.1093/molbev/msad200
  5. Aguirre J, Atanasova M, ........ Steiner RA,....Wojdyr M, Yamashita K (2023) The CCP4 suite: integrative software for macromolecular crystallography. Acta Crystallogr D Struct Biol. 79, 449-461. doi: 10.1107/S2059798323003595

  Gyorgy Szabadkai

gyorgy.szabadkai@unipd.it

Pubblicazioni:

  1. Menegollo, M. et al. Multistate Gene Cluster Switches Determine the Adaptive Mitochondrial and Metabolic Landscape of Breast Cancer. Cancer Res 84, 2911–2925 (2024)
  2. Chung, C.-Y. et al. Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation. Nat Commun 12, 6409 (2021)
  3. Desai, R. et al. Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response. Sci Adv 6, eabc9955 (2020)
  4. Xu, R. et al. The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism. EMBO Rep 21, e48260 (2020)
  5. Bentham, R. B., Bryson, K. & Szabadkai, G. MCbiclust: a novel algorithm to discover large-scale functionally related gene sets from massive transcriptomics data collections. Nucleic Acids Res 45, 8712–8730

  Regina Tavano

regina.tavano@unipd.it 

Pubblicazioni:

  1. The Topology of Poly(2-methyl-2-oxazine) Shells on Nanoparticles Determines Their Interaction with Serum and Uptake by Immune Cells. Morbidelli M, Romio M, Chandorkar Y, Gogos A, Hirsch C, Kolrosova B, Trachsel L, Lorandi F, Badocco D, Pastore P, Arrigoni G, Franchin C, Tavano R, Hoogenboom R, Papini E*, Benetti EM. Biomacromolecules. 2025 Jan 13;26(1):556-566. doi: 10.1021/acs.biomac.4c01340.
  2. Essential protocols for decoding the composition and the functional effects of the nanoparticle protein corona. Morbidelli M, PapiniE, Tavano R*. Front. Nanotechnol., 2024, 6. doi.org/10.3389
  3. Nanoparticles Based on Cross-Linked Poly(Lipoic Acid) Protect Macrophages and Cardiomyocytes from Oxidative Stress and Ischemia Reperfusion Injury.Bellini C, Antonucci S, Morillas-Becerril L, Scarpa S, Tavano R, Mancin F, Di Lisa F, Papini E*. Antioxidants (Basel). 2022 May 5;11(5):907.
  4. Antioxidants (Basel). 2022 May 5;11(5):907. doi: 10.3390/antiox11050907. Poly(lipoic acid)-Based Nanoparticles as Self-Organized, Biocompatible, and Corona-Free Nanovectors. Trzciński JW, Morillas-Becerril L, Scarpa S, Tannorella M, Muraca F, Rastrelli F, Castellani C, Fedrigo M, Angelini A, Tavano R*, Papini E, Mancin F. Biomacromolecules. 2021 Feb 8;22(2):467-480. doi: 10.1021/acs.biomac.0c01321.
  5. Opsonins and Dysopsonins of Nanoparticles: Facts, Concepts, and Methodological Guidelines. Papini E*, Tavano R, Mancin F. Front Immunol. 2020 Oct 12;11:567365. doi: 10.3389/fimmu.2020.567365

  Luana Toniolo

luana.toniolo@unipd.it

Pubblicazioni:

  1. Toniolo L, Gazzin S, Rosso N, Giraudi P, Bonazza D, Concato M, Zanconati F, Tiribelli C, Giacomello E. Gender Differences in the Impact of a High-Fat, High-Sugar Diet in Skeletal Muscles of Young Female and Male Mice. Nutrients. 2024
  2. Toniolo L, Concato M, Giacomello E. Resveratrol, a Multitasking Molecule That Improves Skeletal Muscle Health. Nutrients. 2023
  3. Toniolo L, Sirago G, Giacomello E. Experimental models for ageing research. Histol Histopathol. 2023
  4. Toniolo L, Sirago G, Fiotti N, Giacomello E. Golgi Complex form and Function:A Potential Hub Role Also in Skeletal Muscle Pathologies? Int J Mol Sci. 2022
  5. Sirago G, Vaccari F, Lazzer S, D'Amuri A, Sanz JM, Narici MV, Reggiani C, Passaro A, Toniolo L. Skeletal Muscle Mitochondrial and Perilipin Content in aCohort of Obese Subjects Undergoing Moderate and High Intensity Training.Metabolites. 2022

  Antonella Viola

antonella.viola@unipd.it

Pubblicazioni:

  1. Sánchez-Rodríguez R., Tezze C., Agnellini A.H.R., Angioni R., Venegas F.C., Cioccarelli C., Munari F., Bertoldi N., Canton M., Desbats M.A., Salviati L., Gissi R., Castegna A., Soriano M.E., Sandri M., Scorrano L., Viola A*, Molon B. 2022 OPA1 drives macrophage metabolism and functional commitment via p65 signaling. Cell Death & Differerentiation doi: 10.1038/s41418-022-01076-y. (*co-last author)
  2. Calì B., Deygas M., Munari F., Marcuzzi E., Cassará A., Toffali L., Vetralla M., Bernard M., Piel M., Gagliano O., Mastrogiovanni M., Laudanna C., Elvassore N., Molon B., Vargas P., Viola A. Atypical CXCL12 signaling enhances neutrophil migration by modulating nuclear deformability. Science Signaling 15(761), eabk2552
  3. Angioni R., …Viola A*., Testa G. RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity. Cell Report Medicine 2023, DOI: 10.1016/j.xcrm.2023.101266 (*co-last author)
  4. Venegas FC, Sánchez-Rodríguez R, Luisetto R, Angioni R, Viola A*, Canton M. Oxidative Stress by the Mitochondrial Monoamine Oxidase B Mediates Calcium Pyrophosphate Crystal-Induced Arthritis. Arthritis Rheumatol. 2024 doi: 10.1002/art.42697. (*co-last author)
  5. Feno S., Munari F., Reane D.V., Gissi R., Hoang D.H., Castegna A., Chazaud B., Viola A*., Rizzuto R., Raffaello A. 2021. The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration. Science Signalling 14(707):eabf3838. (* co-last author).

  Carlo Fiore Viscomi

carlo.viscomi@unipd.it

  Pompeo Volpe

pompeo.volpe@unipd.it

Pubblicazioni:

  1. M. A. Munger, Y. Olğar, M. Koleske, H. L. Struckman, J. Mandroli, Q. Lou, I. Bonila, K. Kim, R. Ramos Mondragon, S. G. Priori, P. Volpe, H. H. Valdivia, J. Biskupiak, C. A. Carnes, R. Veeraraghavan, S. Györke and P. B. Radwański. Tetrodotoxin-sensitive neuronal-type Na+ channels: a novel and druggable target for prevention of atrial fibrillation. J. Am. Heart Assoc. 2020, Jun 2; 9(11): e015119, 2020
  2. G. Valle, M. Arad and P. Volpe. Molecular adaptation to calsequestrin 2 (CASQ2) point mutations leading to catecholaminergic polymorphic ventricular tachycardia (CPVT): comparative analysis of R33Q and D307H mutants. J. Muscle Res. Cell Motil. 41: 251-258, 2020
  3. P. Lorenzon, S. Furlan, B. Ravara, A. Bosutti, G. Massaria, A. Bernareggi, M. Sciancalepore, G. Trautmann, K. Block, D. Blottner, P. F. Worley, S. Zampieri, M. Salanova and P. Volpe. Preliminary observations on skeletal muscle adaptation and plasticity in Homer 2-/- mice. Metabolites 2021, Sep, 11(9), 642, 2021
  4. P. Volpe, A. Bosutti, A. Nori, R. Filadi, G. Gherardi, G. Trautmann, S. Furlan, G. Massaria, M. Sciancalepore, A. Megighian, P. Caccin, A. Bernareggi, M. Salanova, R. Sacchetto, D. Sandonà, P. Pizzo and P. Lorenzon. Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptors at the neuromuscular junction. J. Gen. Physiol. 154: 1-12, e202213128, 2022
  5. S. Furlan, B. Paradiso, E. Greotti, P. Volpe and A. Nori. Calsequestrin in Purkinje cells of mammalian cerebellum. Acta Histochemica 125, 152001, 1-11, 2023.

  Tania Zaglia

tania.zaglia@unipd.it

Pubblicazioni:

  1. Vanaja IP, Scalco A, Ronfini M, Bona AD, Olianti C, Rizzo S, Chelko SP, Corrado D, Sacconi L, Basso C, Mongillo M, Zaglia T. Cardiac sympathetic neurons are additional cells affected in genetically determined arrhythmogenic cardiomyopathy. J Physiol. 2024 Aug 14. doi: 10.1113/JP286845
  2. Mazzaro A, Vita V, Ronfini M, Casola I, Klein A, Dobrowolny G, Sorarù G, Musarò A, Mongillo M, Zaglia T. Sympathetic neuropathology is revealed in muscles affected by amyotrophic lateral sclerosis. Front Physiol. 2023 May 12;14:1165811. doi: 10.3389/fphys.2023.1165811
  3. Dokshokova L, Franzoso M, Di Bona A, Moro N, Sanchez Alonso JL, Prando V, Sandre M, Basso C, Faggian G, Abriel H, Marin O, Gorelik J, Zaglia T, Mongillo M. Nerve growth factor transfer from cardiomyocytes to innervating sympathetic neurons activates TrkA receptors at the neuro-cardiac junction. J Physiol. 2022 Jun;600(12):2853-2875. doi: 10.1113/JP282828
  4. Moro N, Dokshokova L, Perumal Vanaja I, Prando V, Cnudde SJA, Di Bona A, Bariani R, Schirone L, Bauce B, Angelini A, Sciarretta S, Ghigo A, Mongillo M, Zaglia T.Neurotoxic Effect of Doxorubicin Treatment on Cardiac Sympathetic Neurons. Int J Mol Sci. 2022 Sep 21;23(19):11098. doi: 10.3390/ijms231911098
  5. Stadiotti I, Di Bona A, Pilato CA, Scalco A, Guarino A, Micheli B, Casella M, Tondo C, Rizzo S, Pilichou K, Thiene G, Frigo AC, Pompilio G, Basso C, Sommariva E, Mongillo M, Zaglia T. Neuropeptide Y promotes adipogenesis of human cardiac mesenchymal stromal cells in arrhythmogenic cardiomyopathy. Int J Cardiol. 2021 Nov 1;342:94-102. doi: 10.1016/j.ijcard.2021.08.015.

  Carlo Federico Zambon

carlofederico.zambon@unipd.it

Pubblicazioni:

  1. Circulating Small Noncoding RNA Profiling as a Potential Biomarker of Atherosclerotic Plaque Composition in Type 1 Diabetes. Giannella A, Castelblanco E, Zambon CF, Basso D, Hernandez M, Ortega E, Alonso N, Mauricio D, Avogaro A, Ceolotto G, Vigili de Kreutzenberg S. Diabetes Care. 2023 Mar 1;46(3):551-560. doi: 10.2337/dc22-1441. PMID: 36577032 Free PMC article.
  2. Blood biomarkers for Alzheimer's disease with the Lumipulse automated platform: Age-effect and clinical value interpretation. Musso G, Gabelli C, Puthenparampil M, Cosma C, Cagnin A, Gallo P, Sorarù G, Pegoraro E, Zaninotto M, Antonini A, Moz S, Zambon CF, Plebani M, Corbetta M, Basso D. Clin Chim Acta. 2025 Jan 15;565:120014. doi: 10.1016/j.cca.2024.120014. Epub 2024 Oct 22. PMID: 39442787
  3. Salivary SARS-CoV-2 antigen rapid detection: A prospective cohort study. Basso D, Aita A, Padoan A, Cosma C, Navaglia F, Moz S, Contran N, Zambon CF, Maria Cattelan A, Plebani M. Clin Chim Acta. 2021 Jun;517:54-59. doi: 10.1016/j.cca.2021.02.014. Epub 2021 Feb 21. PMID: 33626369 Free PMC article.
  4. Salivary proteomic analysis in asymptomatic and symptomatic SARS-CoV-2 infection: Innate immunity, taste perception and FABP5 proteins make the difference. Aita A, Battisti I, Contran N, Furlan S, Padoan A, Franchin C, Barbaro F, Cattelan AM, Zambon CF, Plebani M, Basso D, Arrigoni G. Clin Chim Acta. 2022 Dec 1;537:26-37. doi: 10.1016/j.cca.2022.09.023. Epub 2022 Oct 10. PMID: 36228679 Free PMC article.
  5. SARS-CoV-2 RNA identification in nasopharyngeal swabs: issues in pre-analytics. Basso D, Aita A, Navaglia F, Franchin E, Fioretto P, Moz S, Bozzato D, Zambon CF, Martin B, Dal Prà C, Crisanti A, Plebani M. Clin Chem Lab Med. 2020 Jun 22;58(9):1579-1586. doi: 10.1515/cclm-2020-0749. Print 2020 Aug 27. PMID: 32573469